Behavioural and Neurodevelopmental Impairment at School Age Following Necrotising Enterocolitis in the Newborn Period

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2019 Apr 12

PMID 30973924

Citations 4

Authors

Mathias Luhr Hansen

Ida Voss Jensen

Rasmus Gregersen

Sandra Meinich Juhl

Gorm Greisen

Affiliations

Soon will be listed here.

Abstract

Aim: The aim of this study was to evaluate long-term behavioural and neurodevelopmental complications of neonatal necrotizing enterocolitis at school age.

Method: This was a historic cohort study comparing all surviving children born in Denmark between 1st of January 2002 and 31st of December 2011 with a diagnosis of necrotizing enterocolitis to a group of children without necrotizing enterocolitis, but same gestational age, birth weight and year of birth. Outcomes were investigated through a parental questionnaire. The primary outcome was the Strength and Difficulties Questionnaire score and secondary outcomes were cerebral palsy and impaired head growth.

Results: Response rates were 50% (163 of 328) and 36% (237 of 652) among children with and without necrotizing enterocolitis, respectively. There was a higher rate of abnormal Strength and Difficulties score (23.9 versus 17.8%), moderate/severe cerebral palsy (3.1 versus 0.9%) and small head circumference for age (11.7 versus 7.2%) among children with necrotizing enterocolitis. However, these differences were all statistically insignificant and did not change significantly by adjustment for potential confounders.

Conclusion: To our knowledge, this study includes the largest cohort of necrotizing enterocolitis children evaluated for possible long-term complications at school age. The increased risks of behavioural- and neurodevelopmental impairments were statistically insignificant, moderate in magnitude and may be of little clinical importance for management in the neonatal period or when planning follow-up.

Citing Articles

Role of gut-brain axis in neurodevelopmental impairment of necrotizing enterocolitis.

Wang Y, Hang C, Hu J, Li C, Zhan C, Pan J Front Neurosci. 2023; 17:1059552.

PMID: 36743802 PMC: 9894661. DOI: 10.3389/fnins.2023.1059552.

Survey on antibiotic regimens for necrotizing enterocolitis prescribed by Chinese pediatricians in 2020.

Zhang Z, He Y, Wang Z, Bao L, Shi Y, Li L World J Pediatr Surg. 2022; 4(2):e000253.

PMID: 36474777 PMC: 9648576. DOI: 10.1136/wjps-2020-000253.

Long-Term Outcome of Necrotizing Enterocolitis and Spontaneous Intestinal Perforation.

Vaidya R, Yi J, OShea T, Jensen E, Joseph R, Shenberger J Pediatrics. 2022; 150(5).

PMID: 36200375 PMC: 9647591. DOI: 10.1542/peds.2022-056445.

Postnatal Gut Immunity and Microbiota Development Is Minimally Affected by Prenatal Inflammation in Preterm Pigs.

Pan X, Zhang D, Nguyen D, Wei W, Yu X, Gao F Front Immunol. 2020; 11:420.

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