In Silico Validation of the Indigenous Knowledge of the Herbal Medicines Among Tribal Communities in Sathyamangalam Wildlife Sanctuary, India

Overview

Journal J Tradit Complement Med

Specialty Rehabilitation Medicine

Date 2019 Apr 10

PMID 30963049

Citations 1

Authors

Pavithra Chinnasamy

Rajendran Arumugam

Sarvalingam Ariyan

Affiliations

Soon will be listed here.

Abstract

The ethno-botanical documentation among ethnic people in Sathyamangalam wildlife sanctuary, Tamil Nadu, India has been investigated for the first time. A total of 61 medicinal plants having new combination uses were reported with adjuvant in the treatment of dermatological, Genitourinary and gastrointestinal ailments. This study could help in the recovery and conservation of traditional medicine system among educated generation. The present study was aimed to: (1) documentation of the traditional knowledge (2) quantitative analysis using Use value (UV), Informant consensus factor (ICF), Index of agreement on remedies (IAR), Relative frequency citation (RFC) and Cultural Importance index (CII) (3) validation of ethno-botanical data using biological activity and toxicity prediction studies. Semi-structured direct interviews were conducted to acquire information from the study area tribes. Total of 89 tribes including both gender among various communities were interviewed and their ethno-botanical knowledge was documented. The data were assessed using ethno-botanical indices methods to estimate the consistency of usage herbal knowledge in various ailments. A total of 61 species were recorded for treatment of categorized ailments. The collected medicinal information from ethnic groups shows remarkable new usage of medicinal plants to particular ailments. Our comparative studies also supported the traditional medicine results with correspondence to their bioactive. Traditional knowledge of ethnic people also linked to their culture and history. This study also infers the usage of traditional plant based medicine. Further research related to the bioactivities of reported plants should be encouraged to explore the importance in pharmaceutical industry.

Citing Articles

Analgesic and Anti-Arthritic Potential of Methanolic Extract and Palmatine Obtained from Leaves.

Ito C, Santos Procopio E, de Matos Balsalobre N, Machado L, Silva-Filho S, Pedroso T Pharmaceuticals (Basel). 2024; 17(10).

PMID: 39458972 PMC: 11510468. DOI: 10.3390/ph17101331.

References

Valenciennes E, Smadja J, Conan J . Screening for biological activity and chemical composition of Euodia borbonica var. borbonica (Rutaceae), a medicinal plant in Reunion Island. J Ethnopharmacol. 1999; 64(3):283-8. DOI: 10.1016/s0378-8741(98)00137-8. View

Rates S . Plants as source of drugs. Toxicon. 2000; 39(5):603-13. DOI: 10.1016/s0041-0101(00)00154-9. View

Lagunin A, Stepanchikova A, Filimonov D, Poroikov V . PASS: prediction of activity spectra for biologically active substances. Bioinformatics. 2000; 16(8):747-8. DOI: 10.1093/bioinformatics/16.8.747. View

Sharma H, Chhangte L, Dolui A . Traditional medicinal plants in Mizoram, India. Fitoterapia. 2001; 72(2):146-61. DOI: 10.1016/s0367-326x(00)00278-1. View

Arthan D, Svasti J, Kittakoop P, Pittayakhachonwut D, Tanticharoen M, Thebtaranonth Y . Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum. Phytochemistry. 2002; 59(4):459-63. DOI: 10.1016/s0031-9422(01)00417-4. View

Damasceno D, Volpato G, Sartori T, Rodrigues P, Perin E, Calderon I . Effects of Annona squamosa extract on early pregnancy in rats. Phytomedicine. 2002; 9(7):667-72. DOI: 10.1078/094471102321616508. View

Ekins S . Predicting undesirable drug interactions with promiscuous proteins in silico. Drug Discov Today. 2004; 9(6):276-85. DOI: 10.1016/S1359-6446(03)03008-3. View

Katewa S, Chaudhary B, Jain A . Folk herbal medicines from tribal area of Rajasthan, India. J Ethnopharmacol. 2004; 92(1):41-6. DOI: 10.1016/j.jep.2004.01.011. View

Verma S, Singh M, Jain P, Bordia A . Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits. Indian J Exp Biol. 2004; 42(7):736-8. View

10.

Koteswara Rao Y, Vimalamma G, Venkata Rao C, Tzeng Y . Flavonoids and andrographolides from Andrographis paniculata. Phytochemistry. 2004; 65(16):2317-21. DOI: 10.1016/j.phytochem.2004.05.008. View

11.

Gupta R, Kesari A, Murthy P, Chandra R, Tandon V, Watal G . Hypoglycemic and antidiabetic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J Ethnopharmacol. 2005; 99(1):75-81. DOI: 10.1016/j.jep.2005.01.048. View

12.

Gurib-Fakim A . Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2005; 27(1):1-93. DOI: 10.1016/j.mam.2005.07.008. View

13.

Mukherjee P, Wahile A . Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol. 2005; 103(1):25-35. DOI: 10.1016/j.jep.2005.09.024. View

14.

Wu W, Kang Y, Wang N, Jou H, Wang T . Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. J Nutr. 2006; 136(5):1270-5. DOI: 10.1093/jn/136.5.1270. View

15.

Li L, Li X, Shi C, Deng Z, Fu H, Proksch P . Pongamone A-E, five flavonoids from the stems of a mangrove plant, Pongamia pinnata. Phytochemistry. 2006; 67(13):1347-52. DOI: 10.1016/j.phytochem.2006.05.016. View

16.

Brijesh S, Daswani P, Tetali P, Rojatkar S, Antia N, Birdi T . Studies on Pongamia pinnata (L.) Pierre leaves: understanding the mechanism(s) of action in infectious diarrhea. J Zhejiang Univ Sci B. 2006; 7(8):665-74. PMC: 1533752. DOI: 10.1631/jzus.2006.B0665. View

17.

Muthu C, Ayyanar M, Raja N, Ignacimuthu S . Medicinal plants used by traditional healers in Kancheepuram district of Tamil Nadu, India. J Ethnobiol Ethnomed. 2006; 2:43. PMC: 1615867. DOI: 10.1186/1746-4269-2-43. View

18.

Rao Y, Fang S, Tzeng Y . Antiinflammatory activities of flavonoids and a triterpene caffeate isolated from Bauhinia variegata. Phytother Res. 2008; 22(7):957-62. DOI: 10.1002/ptr.2448. View

19.

Iqbal P, Bhat A, Azam A . Antiamoebic coumarins from the root bark of Adina cordifolia and their new thiosemicarbazone derivatives. Eur J Med Chem. 2008; 44(5):2252-9. DOI: 10.1016/j.ejmech.2008.06.003. View

20.

Kosalge S, Fursule R . Investigation of ethnomedicinal claims of some plants used by tribals of Satpuda Hills in India. J Ethnopharmacol. 2008; 121(3):456-61. DOI: 10.1016/j.jep.2008.11.017. View