Correlation of Serum 1,5-AG with Uric Acid in Type 2 Diabetes Mellitus with Different Renal Functions

Overview

Journal Int J Endocrinol

Publisher Wiley

Specialty Endocrinology

Date 2019 Apr 10

PMID 30962807

Citations 2

Authors

Kai Zhang

Bizhen Xue

Yuexing Yuan

Yao Wang

Affiliations

Soon will be listed here.

Abstract

Aim: Recent studies found that levels of serum uric acid (SUA) were positively associated with serum 1,5-anhydroglucitol (1,5-AG) in subjects with type 2 diabetes mellitus (T2DM). In the current study, we investigated the association between 1,5-AG and UA in T2DM patients with different renal functions.

Methods: A total of 405 T2DM patients, 213 men and 192 women, participated in the study. Patients' clinical information was collected, and serum 1,5-AG, SUA, and other clinical characteristics were measured. Correlation analyses were carried out to analyze their correlation with serum 1,5-AG and SUA.

Results: The male group showed higher levels of SUA than the female group (282.1 ± 91.2 and 244.7 ± 71.89 mol/L, respectively, < 0.01). Pearson's correlation coefficients determine that SUA was positively associated with 1,5-AG in both men ( = 0.213, < 0.05) and women ( = 0.223, < 0.05), and such relationship can be influenced by the renal function. The positive association still existed with moderate impaired renal function. Moreover, 1,5-AG had a negative association with haemoglobin A1c (HbA1c) in T2DM subjects with eGFR ≥ 30 mL/min/1.73 m ( < 0.01).

Conclusion: The positive association between SUA and 1,5-AG still exists in T2DM with moderate renal failure. 1,5-AG can still reflect the glucose levels in patients with CKD stages 1-3.

Citing Articles

Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus.

Ortiz-Martinez M, Gonzalez-Gonzalez M, Martagon A, Hlavinka V, Willson R, Rito-Palomares M Curr Diab Rep. 2022; 22(3):95-115.

PMID: 35267140 PMC: 8907395. DOI: 10.1007/s11892-022-01453-4.

Serum levels of 1,5-anhydroglucitol and 1,5-anhydrofructose-derived advanced glycation end products in patients undergoing hemodialysis.

Tanaka K, Sakasai-Sakai A, Motomiya Y, Yoneda T, Takeuchi M Diabetol Metab Syndr. 2021; 13(1):85.

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References

Sumino H, Ichikawa S, Kanda T, Nakamura T, Sakamaki T . Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia. Lancet. 1999; 354(9179):650. DOI: 10.1016/S0140-6736(99)92381-4. View

Hyink D, Rappoport J, Wilson P, Abramson R . Expression of the urate transporter/channel is developmentally regulated in human kidneys. Am J Physiol Renal Physiol. 2001; 281(5):F875-86. DOI: 10.1152/ajprenal.0352.2000. View

Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha S . Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002; 417(6887):447-52. DOI: 10.1038/nature742. View

Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M . SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2004; 76(9):1039-50. DOI: 10.1016/j.lfs.2004.10.016. View

Hisatome I, Sasaki N, Yamakawa M, Kobayashi M, Tanaka Y, Kosaka H . Two cases of persistent hypouricemia associated with diabetes mellitus. Nephron. 1992; 61(2):196-9. DOI: 10.1159/000186871. View

Gotoh M, Li C, Yatoh M, Iguchi A, Hirooka Y . Serum uric acid concentrations in type 2 diabetes: its significant relationship to serum 1,5-anhydroglucitol concentrations. Endocr Regul. 2006; 39(4):119-25. View

Ma Y, Zuo L, Chen J, Luo Q, Yu X, Li Y . Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol. 2006; 17(10):2937-44. DOI: 10.1681/ASN.2006040368. View

Vitart V, Rudan I, Hayward C, Gray N, Floyd J, Palmer C . SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. Nat Genet. 2008; 40(4):437-42. DOI: 10.1038/ng.106. View

Hak A, Choi H . Menopause, postmenopausal hormone use and serum uric acid levels in US women--the Third National Health and Nutrition Examination Survey. Arthritis Res Ther. 2008; 10(5):R116. PMC: 2592803. DOI: 10.1186/ar2519. View

10.

Koga M, Murai J, Saito H, Mukai M, Kasayama S, Moriwaki Y . Close relationship between serum concentrations of 1,5-anhydroglucitol and uric acid in non-diabetic male subjects implies common renal transport system. Clin Chim Acta. 2009; 410(1-2):70-3. DOI: 10.1016/j.cca.2009.09.024. View

11.

Musso G, Gambino R, Cassader M, Pagano G . A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials. Ann Med. 2011; 44(4):375-93. DOI: 10.3109/07853890.2011.560181. View

12.

Bandaru P, Shankar A . Association between Serum Uric Acid Levels and Diabetes Mellitus. Int J Endocrinol. 2011; 2011:604715. PMC: 3216382. DOI: 10.1155/2011/604715. View

13.

Kim W, Park C, Lee K, Park S, Rhee E, Lee W . Serum 1,5-anhydroglucitol concentrations are a reliable index of glycemic control in type 2 diabetes with mild or moderate renal dysfunction. Diabetes Care. 2012; 35(2):281-6. PMC: 3263896. DOI: 10.2337/dc11-1462. View

14.

Ouchi M, Oba K, Aoyama J, Watanabe K, Ishii K, Yano H . Serum uric acid in relation to serum 1,5-anhydroglucitol levels in patients with and without type 2 diabetes mellitus. Clin Biochem. 2013; 46(15):1436-41. DOI: 10.1016/j.clinbiochem.2013.06.003. View

15.

Levin A, Stevens P . Summary of KDIGO 2012 CKD Guideline: behind the scenes, need for guidance, and a framework for moving forward. Kidney Int. 2013; 85(1):49-61. DOI: 10.1038/ki.2013.444. View

16.

Kuo C, Yu K, Shen Y, See L . The Chinese version of the modification of diet in renal disease (MDRD) equation is a superior screening tool for chronic kidney disease among middle-aged Taiwanese than the original MDRD and Cockcroft-Gault equations. Biomed J. 2014; 37(6):398-405. DOI: 10.4103/2319-4170.132886. View

17.

Ma X, Hao Y, Hu X, Luo Y, Deng Z, Zhou J . 1,5-anhydroglucitol is associated with early-phase insulin secretion in chinese patients with newly diagnosed type 2 diabetes mellitus. Diabetes Technol Ther. 2015; 17(5):320-6. DOI: 10.1089/dia.2014.0346. View

18.

Seok H, Huh J, Kim H, Lee B, Kang E, Lee H . 1,5-anhydroglucitol as a useful marker for assessing short-term glycemic excursions in type 1 diabetes. Diabetes Metab J. 2015; 39(2):164-70. PMC: 4411548. DOI: 10.4093/dmj.2015.39.2.164. View

19.

Yamanouchi T, MINODA S, Yabuuchi M, Akanuma Y, Akanuma H, Miyashita H . Plasma 1,5-anhydro-D-glucitol as new clinical marker of glycemic control in NIDDM patients. Diabetes. 1989; 38(6):723-9. DOI: 10.2337/diab.38.6.723. View

20.

Hasslacher C, Kulozik F . Effect of renal function on serum concentration of 1,5-anhydroglucitol in type 2 diabetic patients in chronic kidney disease stages I-III: A comparative study with HbA1c and glycated albumin. J Diabetes. 2015; 8(5):712-9. DOI: 10.1111/1753-0407.12354. View