Long Non-coding RNA SNHG16 Affects Cell Proliferation and Predicts a Poor Prognosis in Patients with Colorectal Cancer Via Sponging MiR-200a-3p

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2019 Apr 10

PMID 30962265

Citations 18

Authors

Yanling Li

Ying Lu

Yanglong Chen

Affiliations

Soon will be listed here.

Abstract

Previous study has explored that SNHG16, a long non-coding RNA (lncRNA), mediated cell growth and proliferation. Yet, the role of SNHG16 in human colorectal cancer (CRC) still remains to be explored. Therefore, we conducted the present study to explore the functions of SNHG16 in CRC. In the present study, SNHG16 was significantly up-regulated in CRC tissues and cell lines. Gain- and loss-of-function of SNHG16 further presented that SNHG16 promoted the progression of CRC cells, including proliferation, migration, and invasion. Further, study also revealed that overexpression of SNHG16 could promote tumor growth. Bioinformatics analysis and luciferase reporter assay showed that SNHG16 was a direct target of miR-200a-3p. MiR-200a-3p was inversely correlated with SNHG16 expression in CRC tissues. In brief, the above results elucidate the important role of SNHG16 in CRC tumorigenesis, suggesting that SNHG16 might be quite vital for the diagnosis and development of CRC.

Citing Articles

Molecular mechanisms underlying roles of long non-coding RNA small nucleolar RNA host gene 16 in digestive system cancers.

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Roles of long non‑coding RNA SNHG16 in human digestive system cancer (Review).

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References

Yang L, Lin C, Jin C, Yang J, Tanasa B, Li W . lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs. Nature. 2013; 500(7464):598-602. PMC: 4034386. DOI: 10.1038/nature12451. View

Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H . Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. Cancer Sci. 2014; 105(8):974-82. PMC: 4317863. DOI: 10.1111/cas.12454. View

Rodriguez-Malave N, Fernando T, Patel P, Contreras J, Palanichamy J, Tran T . BALR-6 regulates cell growth and cell survival in B-lymphoblastic leukemia. Mol Cancer. 2015; 14:214. PMC: 4688921. DOI: 10.1186/s12943-015-0485-z. View

Zheng H, Shi D, Wang Y, Li X, Xu Y, Tripathi P . High expression of lncRNA MALAT1 suggests a biomarker of poor prognosis in colorectal cancer. Int J Clin Exp Pathol. 2014; 7(6):3174-81. PMC: 4097248. View

Li J, Liu S, Zhou H, Qu L, Yang J . starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data. Nucleic Acids Res. 2013; 42(Database issue):D92-7. PMC: 3964941. DOI: 10.1093/nar/gkt1248. View

An X, Sarmiento C, Tan T, Zhu H . Regulation of multidrug resistance by microRNAs in anti-cancer therapy. Acta Pharm Sin B. 2017; 7(1):38-51. PMC: 5237711. DOI: 10.1016/j.apsb.2016.09.002. View

Liu J, Yao J, Li X, Song Y, Wang X, Li Y . Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus. Cell Death Dis. 2014; 5:e1506. PMC: 4649539. DOI: 10.1038/cddis.2014.466. View

Ghazal S, McKinnon B, Zhou J, Mueller M, Men Y, Yang L . H19 lncRNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis. EMBO Mol Med. 2015; 7(8):996-1003. PMC: 4551339. DOI: 10.15252/emmm.201505245. View

Guo G, Kang Q, Zhu X, Chen Q, Wang X, Chen Y . A long noncoding RNA critically regulates Bcr-Abl-mediated cellular transformation by acting as a competitive endogenous RNA. Oncogene. 2014; 34(14):1768-79. DOI: 10.1038/onc.2014.131. View

10.

Cai C, Huo Q, Wang X, Chen B, Yang Q . SNHG16 contributes to breast cancer cell migration by competitively binding miR-98 with E2F5. Biochem Biophys Res Commun. 2017; 485(2):272-278. DOI: 10.1016/j.bbrc.2017.02.094. View

11.

Torre L, Bray F, Siegel R, Ferlay J, Lortet-Tieulent J, Jemal A . Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65(2):87-108. DOI: 10.3322/caac.21262. View

12.

Yang X, Wang G, Luo L . Long non-coding RNA SNHG16 promotes cell growth and metastasis in ovarian cancer. Eur Rev Med Pharmacol Sci. 2018; 22(3):616-622. DOI: 10.26355/eurrev_201802_14284. View

13.

Yang J, Li J, Shao P, Zhou H, Chen Y, Qu L . starBase: a database for exploring microRNA-mRNA interaction maps from Argonaute CLIP-Seq and Degradome-Seq data. Nucleic Acids Res. 2010; 39(Database issue):D202-9. PMC: 3013664. DOI: 10.1093/nar/gkq1056. View

14.

Iguchi T, Uchi R, Nambara S, Saito T, Komatsu H, Hirata H . A long noncoding RNA, lncRNA-ATB, is involved in the progression and prognosis of colorectal cancer. Anticancer Res. 2015; 35(3):1385-8. View

15.

Shi J, Li X, Zhang F, Zhang C, Guan Q, Cao X . Circulating lncRNAs associated with occurrence of colorectal cancer progression. Am J Cancer Res. 2015; 5(7):2258-65. PMC: 4548337. View

16.

Liao Q, He W, Liu J, Cen Y, Luo L, Yu C . Identification and functional annotation of lncRNA genes with hypermethylation in colorectal cancer. Gene. 2015; 572(2):259-65. DOI: 10.1016/j.gene.2015.07.028. View

17.

Broderick J, Zamore P . Competitive endogenous RNAs cannot alter microRNA function in vivo. Mol Cell. 2014; 54(5):711-3. DOI: 10.1016/j.molcel.2014.05.023. View

18.

Christensen L, True K, Hamilton M, Nielsen M, Damas N, Damgaard C . SNHG16 is regulated by the Wnt pathway in colorectal cancer and affects genes involved in lipid metabolism. Mol Oncol. 2016; 10(8):1266-82. PMC: 5423192. DOI: 10.1016/j.molonc.2016.06.003. View

19.

Pichler M, Ress A, Winter E, Stiegelbauer V, Karbiener M, Schwarzenbacher D . MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients. Br J Cancer. 2014; 110(6):1614-21. PMC: 3960623. DOI: 10.1038/bjc.2014.51. View

20.

Brody H . Colorectal cancer. Nature. 2015; 521(7551):S1. DOI: 10.1038/521S1a. View