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The Life Expectancy of Patients with Metabolic Syndrome After Weight Loss: Study Protocol for a Randomized Clinical Trial (LIFEXPE-RT)

Overview
Journal Trials
Publisher Biomed Central
Specialties General Medicine
Pharmacology
Date 2019 Apr 10
PMID 30961631
Citations 3
Authors
Oral Ospanov
Galymzhan Yeleuov
Irina Kadyrova
Farida Bekmurzinova
Affiliations
Soon will be listed here.
Abstract

Background: To date, surgeons and physicians have found positive results treating metabolic syndrome with surgical and non-surgical weight loss therapies. The purpose of this study was to evaluate changes in telomere length in patients with metabolic syndrome after weight loss.

Methods/design: This study is a three-arm randomized controlled trial. The first group is composed of patients who have undergone stapleless bypass surgery (one anastomosis gastric bypass with an obstructive stapleless pouch and anastomosis (LOAGB-OSPAN)). The second group of patients underwent standard gastric bypass surgery (laparoscopic mini-gastric bypass-one anastomosis gastric bypass (LMGB-OAGB). The patients in the third group received non-surgical weight loss therapy, including a hypocaloric diet with energy restriction (- 500 kcal/day). The aim is to compare changes-telomere length, body mass index, comorbidities, and quality of life-in patients with metabolic syndrome after weight loss.

Discussion: To the best of our knowledge, this is the first randomized study to simultaneously compare the effects of surgical and non-surgical weight loss on changes in telomere length. It could provide a solution to the growing problem of metabolic syndrome. Normalization of the body mass index results in improvements in the health of patients with metabolic syndrome.

Trial Registration: ClinicalTrials.gov, NCT03667469 . Registered on 11 September 2018.

Citing Articles

Surgery for the treatment of obesity in children and adolescents.

Torbahn G, Brauchmann J, Axon E, Clare K, Metzendorf M, Wiegand S Cochrane Database Syst Rev. 2022; 9:CD011740.

PMID: 36074911 PMC: 9454261. DOI: 10.1002/14651858.CD011740.pub2.

Stapleless vs Stapled Gastric Bypass vs Hypocaloric Diet: a Three-Arm Randomized Controlled Trial of Body Mass Evolution with Secondary Outcomes for Telomere Length and Metabolic Syndrome Changes.

Ospanov O, Akilzhanova A, Buchwald J, Fursov A, Bekmurzinova F, Rakhimova S Obes Surg. 2021; 31(7):3165-3176.

PMID: 33963974 DOI: 10.1007/s11695-021-05454-2.

Correction to: The life expectancy of patients with metabolic syndrome after weight loss: study protocol for a randomized clinical trial (LIFEXPE-RT).

Ospanov O, Yeleuov G, Kadyrova I, Bekmurzinova F Trials. 2019; 20(1):716.

PMID: 31831059 PMC: 6907125. DOI: 10.1186/s13063-019-3861-y.

References
1.
Baker R, Foote J, Kemmeter P, Brady R, Vroegop T, Serveld M . The science of stapling and leaks. Obes Surg. 2004; 14(10):1290-8. DOI: 10.1381/0960892042583888. View
2.
Park H, Song Y, Cho S . Obesity has a greater impact on cardiovascular mortality in younger men than in older men among non-smoking Koreans. Int J Epidemiol. 2005; 35(1):181-7. DOI: 10.1093/ije/dyi213. View
3.
OCallaghan N, Clifton P, Noakes M, Fenech M . Weight loss in obese men is associated with increased telomere length and decreased abasic sites in rectal mucosa. Rejuvenation Res. 2009; 12(3):169-76. DOI: 10.1089/rej.2008.0819. View
4.
Carelli A, Youn H, Kurian M, Ren C, Fielding G . Safety of the laparoscopic adjustable gastric band: 7-year data from a U.S. center of excellence. Surg Endosc. 2010; 24(8):1819-23. DOI: 10.1007/s00464-009-0858-8. View
5.
Njajou O, Cawthon R, Blackburn E, Harris T, Li R, Sanders J . Shorter telomeres are associated with obesity and weight gain in the elderly. Int J Obes (Lond). 2011; 36(9):1176-9. PMC: 3408817. DOI: 10.1038/ijo.2011.196. View