Esophageal Adenocarcinoma with Leukemoid Reaction: a Case Report

Overview

Journal J Cardiothorac Surg

Publisher Biomed Central

Specialties Cardiology & Vascular Diseases
General Surgery
Pulmonary Medicine

Date 2019 Apr 10

PMID 30961609

Citations 3

Authors

Ge Yu

Huaijun Ji

Chuizheng Meng

Yixuan Huang

Guogang Gao

Chuanping Liu

Shanlei Wang

Lei Zhang

Jin Ju

Affiliations

Soon will be listed here.

Abstract

Background: Leukemoid reaction (LR) is defined as a reactive leucocytosis with WBC counts exceeding 50,000/mm, and a significant increase in early neutrophil precursors. LR may be a paraneoplastic manifestation of various malignant tumors. Tumor-related LR is a kind of neoplastic syndrome, unrelated to an infection or other diseases.

Case Presentation: A 74-year-old male visited a local doctor with a 20-day history of progressive dysphagia. The complete blood count revealed leucocytosis. Bone marrow aspirates and a biopsy confirmed LR and excluded chronic myelogenous leukemia. Following radical esophagectomy for an adenocarcinoma the WBC counts successively decreased to 10,450/mm and 8670/mm within 1 week and 1 month, respectively.

Conclusion: We report a rare case of esophageal adenocarcinoma complicated with excessive leucocytosis caused by paraneoplastic LR; we also present a review of literature and an investigation of the clinical features. To our knowledge, this is the first report of LR associated with esophageal adenocarcinoma.

Citing Articles

Paraneoplastic leukemoid reaction in a localised squamous cell oesophageal cancer with paracrine G-CSF production.

Azzam O, Hewavitharana C, Fermoyle S, Prentice D BMJ Case Rep. 2020; 13(10).

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Paraneoplastic syndrome in undifferentiated embryonic sarcoma of the liver.

Perl R, Haring A, Horger M, Pfannenberg C, Gatidis S EJNMMI Res. 2020; 10(1):11.

PMID: 32072333 PMC: 7028890. DOI: 10.1186/s13550-020-0602-x.

Paraneoplastic Leukemoid Reaction in Gastroesophageal Junction Adenocarcinoma: A Case Report.

Chang K, Kwok L, Rana M, Patel S, Birris T Am J Case Rep. 2020; 21:e919596.

PMID: 32001665 PMC: 7011169. DOI: 10.12659/AJCR.919596.

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