Incorporation of Conductive Materials into Hydrogels for Tissue Engineering Applications

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2019 Apr 10

PMID 30961003

Citations 44

Authors

Ji Hong Min

Madhumita Patel

Won-Gun Koh

Affiliations

Soon will be listed here.

Abstract

In the field of tissue engineering, conductive hydrogels have been the most effective biomaterials to mimic the biological and electrical properties of tissues in the human body. The main advantages of conductive hydrogels include not only their physical properties but also their adequate electrical properties, which provide electrical signals to cells efficiently. However, when introducing a conductive material into a non-conductive hydrogel, a conflicting relationship between the electrical and mechanical properties may develop. This review examines the strengths and weaknesses of the generation of conductive hydrogels using various conductive materials such as metal nanoparticles, carbons, and conductive polymers. The fabrication method of blending, coating, and in situ polymerization is also added. Furthermore, the applications of conductive hydrogel in cardiac tissue engineering, nerve tissue engineering, and bone tissue engineering and skin regeneration are discussed in detail.

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References

Spencer A, Primbetova A, Koppes A, Koppes R, Fenniri H, Annabi N . Electroconductive Gelatin Methacryloyl-PEDOT:PSS Composite Hydrogels: Design, Synthesis, and Properties. ACS Biomater Sci Eng. 2021; 4(5):1558-1567. PMC: 11150039. DOI: 10.1021/acsbiomaterials.8b00135. View

Zhang H, Chen B, Jiang H, Wang C, Wang H, Wang X . A strategy for ZnO nanorod mediated multi-mode cancer treatment. Biomaterials. 2010; 32(7):1906-14. DOI: 10.1016/j.biomaterials.2010.11.027. View

Ghasemi-Mobarakeh L, Prabhakaran M, Morshed M, Nasr-Esfahani M, Baharvand H, Kiani S . Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering. J Tissue Eng Regen Med. 2011; 5(4):e17-35. DOI: 10.1002/term.383. View

Liu Y, Yu D, Zeng C, Miao Z, Dai L . Biocompatible graphene oxide-based glucose biosensors. Langmuir. 2010; 26(9):6158-60. DOI: 10.1021/la100886x. View

Kharaziha M, Shin S, Nikkhah M, Topkaya S, Masoumi N, Annabi N . Tough and flexible CNT-polymeric hybrid scaffolds for engineering cardiac constructs. Biomaterials. 2014; 35(26):7346-54. PMC: 4114042. DOI: 10.1016/j.biomaterials.2014.05.014. View

Prabhakaran M, Ghasemi-Mobarakeh L, Jin G, Ramakrishna S . Electrospun conducting polymer nanofibers and electrical stimulation of nerve stem cells. J Biosci Bioeng. 2011; 112(5):501-7. DOI: 10.1016/j.jbiosc.2011.07.010. View

Wang H, Han H, Ma Z . Conductive hydrogel composed of 1,3,5-benzenetricarboxylic acid and Fe used as enhanced electrochemical immunosensing substrate for tumor biomarker. Bioelectrochemistry. 2017; 114:48-53. DOI: 10.1016/j.bioelechem.2016.12.006. View

Yang K, Gong H, Shi X, Wan J, Zhang Y, Liu Z . In vivo biodistribution and toxicology of functionalized nano-graphene oxide in mice after oral and intraperitoneal administration. Biomaterials. 2013; 34(11):2787-95. DOI: 10.1016/j.biomaterials.2013.01.001. View

Strakosas X, Wei B, Martin D, Owens R . Biofunctionalization of polydioxythiophene derivatives for biomedical applications. J Mater Chem B. 2020; 4(29):4952-4968. DOI: 10.1039/c6tb00852f. View

10.

Shvedova A, Castranova V, Kisin E, Schwegler-Berry D, Murray A, Gandelsman V . Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J Toxicol Environ Health A. 2003; 66(20):1909-26. DOI: 10.1080/713853956. View

11.

Novoselov K, Falko V, Colombo L, Gellert P, Schwab M, Kim K . A roadmap for graphene. Nature. 2012; 490(7419):192-200. DOI: 10.1038/nature11458. View

12.

Xiang D, Zheng Y, Duan W, Li X, Yin J, Shigdar S . Inhibition of A/Human/Hubei/3/2005 (H3N2) influenza virus infection by silver nanoparticles in vitro and in vivo. Int J Nanomedicine. 2013; 8:4103-13. PMC: 3817021. DOI: 10.2147/IJN.S53622. View

13.

Ahadian S, Yamada S, Ramon-Azcon J, Estili M, Liang X, Nakajima K . Hybrid hydrogel-aligned carbon nanotube scaffolds to enhance cardiac differentiation of embryoid bodies. Acta Biomater. 2015; 31:134-143. DOI: 10.1016/j.actbio.2015.11.047. View

14.

Lee G, Cooper R, An S, Lee S, van der Zande A, Petrone N . High-strength chemical-vapor-deposited graphene and grain boundaries. Science. 2013; 340(6136):1073-6. DOI: 10.1126/science.1235126. View

15.

Patton A, Poole-Warren L, Green R . Mechanisms for Imparting Conductivity to Nonconductive Polymeric Biomaterials. Macromol Biosci. 2016; 16(8):1103-21. DOI: 10.1002/mabi.201600057. View

16.

Dong R, Zhao X, Guo B, Ma P . Self-Healing Conductive Injectable Hydrogels with Antibacterial Activity as Cell Delivery Carrier for Cardiac Cell Therapy. ACS Appl Mater Interfaces. 2016; 8(27):17138-50. DOI: 10.1021/acsami.6b04911. View

17.

Demirtas T, Irmak G, Gumusderelioglu M . A bioprintable form of chitosan hydrogel for bone tissue engineering. Biofabrication. 2017; 9(3):035003. DOI: 10.1088/1758-5090/aa7b1d. View

18.

Kurniawan D, Nor F, Lee H, Lim J . Elastic properties of polycaprolactone at small strains are significantly affected by strain rate and temperature. Proc Inst Mech Eng H. 2011; 225(10):1015-20. DOI: 10.1177/0954411911413059. View

19.

Sun H, Zhou J, Huang Z, Qu L, Lin N, Liang C . Carbon nanotube-incorporated collagen hydrogels improve cell alignment and the performance of cardiac constructs. Int J Nanomedicine. 2017; 12:3109-3120. PMC: 5399986. DOI: 10.2147/IJN.S128030. View

20.

Kai D, Prabhakaran M, Jin G, Ramakrishna S . Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering. J Biomed Mater Res A. 2011; 99(3):376-85. DOI: 10.1002/jbm.a.33200. View