Rational Development of a Novel Hydrogel As a PH-Sensitive Controlled Release System for Nifedipine

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2019 Apr 10

PMID 30960732

Citations 7

Authors

Fabian Avila-Salas

Yeray A Rodriguez Nunez

Adolfo Marican

Ricardo I Castro

Jorge Villasenor

Leonardo S Santos

Sergio Wehinger

Esteban F Duran-Lara

Affiliations

Soon will be listed here.

Abstract

This work depicts the rational development (in-silico design, synthesis, characterization and in-vitro evaluation) of polyvinyl alcohol hydrogels (PVAH) cross-linked with maleic acid (MA) and linked to γ-cyclodextrin molecules (γ-CDPVAHMA) as systems for the controlled and sustained release of nifedipine (NFD). Through computational studies, the structural blocks (PVA chain + dicarboxylic acid + γ-CD) of 20 different hydrogels were evaluated to test their interaction energies (Δ) with NFD. According to the Δ obtained, the hydrogel cross-linked with maleic acid was selected. To characterize the intermolecular interactions between NFD and γ-CDPVAHMA, molecular dynamics simulation studies were carried out. Experimentally, three hydrogel formulations with different proportions of γ-CD (2.43%, 3.61% and 4.76%) were synthesized and characterized. Both loading and release of NFD from the hydrogels were evaluated at acid and basic pH. The computational and experimental results show that γ-CDs linked to the hydrogels were able to form 1:1 inclusion complexes with NFD molecules. Finally, γ-CDPVAHMA-3 demonstrated to be the best pH-sensitive release platform for nifedipine. Its effectiveness could significantly reduce the adverse effects caused by the anticipated release of NFD in the stomach of patients.

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