Validation of Hippocampal Biomarkers of Cumulative Affective Experience

Overview

Journal Neurosci Biobehav Rev

Specialties Neurology
Psychology
Social Sciences

Date 2019 Apr 6

PMID 30951763

Citations 8

Authors

Colline Poirier

Melissa Bateson

Fabio Gualtieri

Elena A Armstrong

Grace C Laws

Timothy Boswell

Tom V Smulders

Affiliations

Soon will be listed here.

Abstract

Progress in improving the welfare of captive animals has been hindered by a lack of objective indicators to assess the quality of lifetime experience, often called cumulative affective experience. Recent developments in stress biology and psychiatry have shed new light on the role of the mammalian hippocampus in affective processes. Here we review these findings and argue that structural hippocampal biomarkers demonstrate criterion, construct and content validity as indicators of cumulative affective experience in mammals. We also briefly review emerging findings in birds and fish, which have promising implications for applying the hippocampal approach to these taxa, but require further validation. We hope that this review will motivate welfare researchers and neuroscientists to explore the potential of hippocampal biomarkers of cumulative affective experience.

Citing Articles

Vulnerability of the Hippocampus to Insults: Links to Blood-Brain Barrier Dysfunction.

Davidson T, Stevenson R Int J Mol Sci. 2024; 25(4).

PMID: 38396670 PMC: 10888241. DOI: 10.3390/ijms25041991.

What is the role of the hippocampus and parahippocampal gyrus in the persistence of tinnitus?.

Berger J, Billig A, Sedley W, Kumar S, Griffiths T, Gander P Hum Brain Mapp. 2024; 45(3):e26627.

PMID: 38376166 PMC: 10878198. DOI: 10.1002/hbm.26627.

Waking inactivity as a welfare indicator in laboratory mice: investigating postures, facial expressions and depression-like states.

MacLellan A, Nazal B, Young L, Mason G R Soc Open Sci. 2022; 9(11):221083.

PMID: 36340516 PMC: 9627452. DOI: 10.1098/rsos.221083.

Using non-invasive neuroimaging to enhance the care, well-being and experimental outcomes of laboratory non-human primates (monkeys).

Basso M, Frey S, Guerriero K, Jarraya B, Kastner S, Koyano K Neuroimage. 2020; 228:117667.

PMID: 33359353 PMC: 8005297. DOI: 10.1016/j.neuroimage.2020.117667.

Beyond MRI: on the scientific value of combining non-human primate neuroimaging with metadata.

Poirier C, Hamed S, Garcia-Saldivar P, Kwok S, Meguerditchian A, Merchant H Neuroimage. 2020; 228:117679.

PMID: 33359343 PMC: 7903159. DOI: 10.1016/j.neuroimage.2020.117679.

References

van Praag H, Kempermann G, Gage F . Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci. 1999; 2(3):266-70. DOI: 10.1038/6368. View

Maguire E, Gadian D, Johnsrude I, Good C, Ashburner J, Frackowiak R . Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci U S A. 2000; 97(8):4398-403. PMC: 18253. DOI: 10.1073/pnas.070039597. View

Lemaire V, Koehl M, Le Moal M, Abrous D . Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A. 2000; 97(20):11032-7. PMC: 27143. DOI: 10.1073/pnas.97.20.11032. View

Tanapat P, Hastings N, Rydel T, Galea L, Gould E . Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism. J Comp Neurol. 2001; 437(4):496-504. DOI: 10.1002/cne.1297. View

Sullivan E, Pfefferbaum A, Swan G, Carmelli D . Heritability of hippocampal size in elderly twin men: equivalent influence from genes and environment. Hippocampus. 2002; 11(6):754-62. DOI: 10.1002/hipo.1091. View

Pham K, Nacher J, Hof P, McEwen B . Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus. Eur J Neurosci. 2003; 17(4):879-86. DOI: 10.1046/j.1460-9568.2003.02513.x. View

Brown K, Ryan R . The benefits of being present: mindfulness and its role in psychological well-being. J Pers Soc Psychol. 2003; 84(4):822-48. DOI: 10.1037/0022-3514.84.4.822. View

Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S . Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003; 301(5634):805-9. DOI: 10.1126/science.1083328. View

Merali Z, Levac C, Anisman H . Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice. Biol Psychiatry. 2003; 54(5):552-65. DOI: 10.1016/s0006-3223(02)01827-9. View

10.

Cronbach L, Meehl P . Construct validity in psychological tests. Psychol Bull. 1955; 52(4):281-302. DOI: 10.1037/h0040957. View

11.

Dulawa S, Holick K, Gundersen B, Hen R . Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacology. 2004; 29(7):1321-30. DOI: 10.1038/sj.npp.1300433. View

12.

Bannerman D, Rawlins J, McHugh S, Deacon R, Yee B, Bast T . Regional dissociations within the hippocampus--memory and anxiety. Neurosci Biobehav Rev. 2004; 28(3):273-83. DOI: 10.1016/j.neubiorev.2004.03.004. View

13.

Pravosudov V, Omanska A . Dominance-related changes in spatial memory are associated with changes in hippocampal cell proliferation rates in mountain chickadees. J Neurobiol. 2004; 62(1):31-41. DOI: 10.1002/neu.20065. View

14.

Paul E, Harding E, Mendl M . Measuring emotional processes in animals: the utility of a cognitive approach. Neurosci Biobehav Rev. 2005; 29(3):469-91. DOI: 10.1016/j.neubiorev.2005.01.002. View

15.

Eadie B, Redila V, Christie B . Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. J Comp Neurol. 2005; 486(1):39-47. DOI: 10.1002/cne.20493. View

16.

Pruessner J, Baldwin M, Dedovic K, Renwick R, Mahani N, Lord C . Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood. Neuroimage. 2005; 28(4):815-26. DOI: 10.1016/j.neuroimage.2005.06.014. View

17.

Kozorovitskiy Y, Gross C, Kopil C, Battaglia L, McBreen M, Stranahan A . Experience induces structural and biochemical changes in the adult primate brain. Proc Natl Acad Sci U S A. 2005; 102(48):17478-82. PMC: 1297690. DOI: 10.1073/pnas.0508817102. View

18.

Mitra R, Sundlass K, Parker K, Schatzberg A, Lyons D . Social stress-related behavior affects hippocampal cell proliferation in mice. Physiol Behav. 2006; 89(2):123-7. DOI: 10.1016/j.physbeh.2006.05.047. View

19.

Nikolakopoulou A, Dermon C, Panagis L, Pavlidis M, Stewart M . Passive avoidance training is correlated with decreased cell proliferation in the chick hippocampus. Eur J Neurosci. 2006; 24(9):2631-42. DOI: 10.1111/j.1460-9568.2006.05133.x. View

20.

Boissy A, Manteuffel G, Jensen M, Moe R, Spruijt B, Keeling L . Assessment of positive emotions in animals to improve their welfare. Physiol Behav. 2007; 92(3):375-97. DOI: 10.1016/j.physbeh.2007.02.003. View