The Histological and Ultrastructural Features of the Epiphyseal Plate in Morquio Type A Syndrome (mucopolysaccharidosis Type IVA)

Overview

Journal Pathology

Specialty Pathology

Date 1986 Apr 1

PMID 3093960

Citations 10

Authors

J McClure

P S Smith

J Hopwood

Affiliations

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Abstract

Tissue from the epiphyseal plate of a patient with Morquio type A syndrome (mucopolysaccharidosis type IVA) was studied by undecalcified histological and electron microscopical techniques. Cartilage cells in the plate were vacuolated to a variable degree. The orderly proliferating structure of the epiphyseal plate was absent and calcification was markedly reduced. The related bone tissue was morphologically normal although reduced in quantity.

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