Effects of Acute Kidney Dysfunction on Hypothalamic Arginine Vasopressin Synthesis in Transgenic Rats

Overview

Journal J Physiol Sci

Specialty Physiology

Date 2019 Apr 3

PMID 30937882

Citations 3

Authors

Hiromichi Ueno

Ryota Serino

Kenya Sanada

Yasuki Akiyama

Kentaro Tanaka

Haruki Nishimura

Kazuaki Nishimura

Satomi Sonoda

Yasuhito Motojima

Reiko Saito

Mitsuhiro Yoshimura

Takashi Maruyama

Tetsu Miyamoto

Masahito Tamura

Yutaka Otsuji

Yoichi Ueta

Affiliations

Soon will be listed here.

Abstract

Acute loss of kidney function is a critical internal stressor. Arginine vasopressin (AVP) present in the parvocellular division of the paraventricular nucleus (PVN) plays a key role in the regulation of stress responses. However, hypothalamic AVP dynamics during acute kidney dysfunction remain unclear. In this study, we investigated the effects of bilateral nephrectomy on AVP, using a transgenic rat line that expressed the AVP-enhanced green fluorescent protein (eGFP). The eGFP fluorescent intensities in the PVN were dramatically increased after bilateral nephrectomy. The mRNA levels of eGFP, AVP, and corticotrophin-releasing hormone in the PVN were dramatically increased after bilateral nephrectomy. Bilateral nephrectomy also increased the levels of Fos-like immunoreactive cells in brainstem neurons. These results indicate that bilateral nephrectomy upregulates the AVP-eGFP synthesis. Further studies are needed to identify the neural and/or humoral factors that activate AVP synthesis and regulate neuronal circuits during acute kidney dysfunction.

Citing Articles

Upregulation of the hypothalamo-neurohypophysial system and activation of vasopressin neurones attenuates hyperalgesia in a neuropathic pain model rat.

Baba K, Kawasaki M, Nishimura H, Suzuki H, Matsuura T, Ikeda N Sci Rep. 2022; 12(1):13046.

PMID: 35906406 PMC: 9338054. DOI: 10.1038/s41598-022-17477-5.

Oxytocin-monomeric red fluorescent protein 1 synthesis in the hypothalamus under osmotic challenge and acute hypovolemia in a transgenic rat line.

Ueno H, Sanada K, Miyamoto T, Baba K, Tanaka K, Nishimura H Physiol Rep. 2020; 8(17):e14558.

PMID: 32914562 PMC: 7507703. DOI: 10.14814/phy2.14558.

Peripherally administered cisplatin activates a parvocellular neuronal subtype expressing arginine vasopressin and enhanced green fluorescent protein in the paraventricular nucleus of a transgenic rat.

Akiyama Y, Yoshimura M, Ueno H, Sanada K, Tanaka K, Sonoda S J Physiol Sci. 2020; 70(1):35.

PMID: 32650712 PMC: 10717609. DOI: 10.1186/s12576-020-00764-z.

References

Itoi K, Helmreich D, Watson S . Differential regulation of corticotropin-releasing hormone and vasopressin gene transcription in the hypothalamus by norepinephrine. J Neurosci. 1999; 19(13):5464-72. PMC: 6782334. View

Vita G, Bellinghieri G, Trusso A, Costantino G, Santoro D, Monteleone F . Uremic autonomic neuropathy studied by spectral analysis of heart rate. Kidney Int. 1999; 56(1):232-7. DOI: 10.1046/j.1523-1755.1999.00511.x. View

Kinoshita H, Jessop D, Finn D, Harbuz M . Cyanamide-induced activation of the hypothalamo-pituitary-adrenal axis. J Neuroendocrinol. 2000; 12(3):255-62. DOI: 10.1046/j.1365-2826.2000.00449.x. View

Helmreich D, Itoi K, Akil H, Watson S . Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus: differential regulation by corticosterone. Brain Res Mol Brain Res. 2001; 88(1-2):62-73. DOI: 10.1016/s0169-328x(01)00018-3. View

ITAGAKI E, Ozawa S, Yamaguchi S, Ushikawa K, Tashiro T, KATAHIRA H . Increases in plasma ACTH and cortisol after hypertonic saline infusion in patients with central diabetes insipidus. J Clin Endocrinol Metab. 2001; 86(12):5749-54. DOI: 10.1210/jcem.86.12.8073. View

Cunningham J, Grindstaff R, Grindstaff R, Sullivan M . Fos immunoreactivity in the diagonal band and the perinuclear zone of the supraoptic nucleus after hypertension and hypervolaemia in unanaesthetized rats. J Neuroendocrinol. 2002; 14(3):219-27. DOI: 10.1046/j.0007-1331.2001.00765.x. View

McKinley M, Mathai M, McAllen R, McClear R, Miselis R, Pennington G . Vasopressin secretion: osmotic and hormonal regulation by the lamina terminalis. J Neuroendocrinol. 2004; 16(4):340-7. DOI: 10.1111/j.0953-8194.2004.01184.x. View

Ueta Y, Fujihara H, Serino R, Dayanithi G, Ozawa H, Matsuda K . Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat. Endocrinology. 2004; 146(1):406-13. DOI: 10.1210/en.2004-0830. View

Fujio T, Fujihara H, Shibata M, Yamada S, Onaka T, Tanaka K . Exaggerated response of arginine vasopressin-enhanced green fluorescent protein fusion gene to salt loading without disturbance of body fluid homeostasis in rats. J Neuroendocrinol. 2006; 18(10):776-85. DOI: 10.1111/j.1365-2826.2006.01476.x. View

10.

Fernandez B, DOMINGUEZ A . Effects of angiotensin II and bilateral nephrectomy on norepinephrine catabolism in central nervous system. Arch Int Physiol Biochim. 1990; 98(6):307-13. DOI: 10.3109/13813459009113991. View

11.

Shibata M, Fujihara H, Suzuki H, Ozawa H, Kawata M, Dayanithi G . Physiological studies of stress responses in the hypothalamus of vasopressin-enhanced green fluorescent protein transgenic rat. J Neuroendocrinol. 2007; 19(4):285-92. DOI: 10.1111/j.1365-2826.2007.01532.x. View

12.

Cruz J, Bonagamba L, Machado B, Biancardi V, Stern J . Intermittent activation of peripheral chemoreceptors in awake rats induces Fos expression in rostral ventrolateral medulla-projecting neurons in the paraventricular nucleus of the hypothalamus. Neuroscience. 2008; 157(2):463-72. PMC: 2700055. DOI: 10.1016/j.neuroscience.2008.08.070. View

13.

Suzuki H, Onaka T, Kasai M, Kawasaki M, Ohnishi H, Otsubo H . Response of arginine vasopressin-enhanced green fluorescent protein fusion gene in the hypothalamus of adjuvant-induced arthritic rats. J Neuroendocrinol. 2009; 21(3):183-90. DOI: 10.1111/j.1365-2826.2009.01818.x. View

14.

Ferrario C, Varagic J, Habibi J, Nagata S, Kato J, Chappell M . Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol. 2009; 296(4):H1184-92. PMC: 2670698. DOI: 10.1152/ajpheart.01114.2008. View

15.

Suzuki H, Kawasaki M, Ohnishi H, Otsubo H, Ohbuchi T, Katoh A . Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat. J Neurosci. 2009; 29(42):13182-9. PMC: 6665199. DOI: 10.1523/JNEUROSCI.2624-09.2009. View

16.

Kawai S, Takagi Y, Kaneko S, Kurosawa T . Effect of three types of mixed anesthetic agents alternate to ketamine in mice. Exp Anim. 2011; 60(5):481-7. DOI: 10.1538/expanim.60.481. View

17.

Yoshimura M, Hagimoto M, Matsuura T, Ohkubo J, Ohno M, Maruyama T . Effects of food deprivation on the hypothalamic feeding-regulating peptides gene expressions in serotonin depleted rats. J Physiol Sci. 2013; 64(2):97-104. PMC: 10717885. DOI: 10.1007/s12576-013-0296-1. View

18.

Oshima N, Onimaru H, Matsubara H, Uchida T, Watanabe A, Takechi H . Uric acid, indoxyl sulfate, and methylguanidine activate bulbospinal neurons in the RVLM via their specific transporters and by producing oxidative stress. Neuroscience. 2015; 304:133-45. DOI: 10.1016/j.neuroscience.2015.07.055. View

19.

Simon J, Kasting N, Ciriello J . Afferent renal nerve effects on plasma vasopressin and oxytocin in conscious rats. Am J Physiol. 1989; 256(6 Pt 2):R1240-4. DOI: 10.1152/ajpregu.1989.256.6.R1240. View

20.

So M, Hashimoto H, Saito R, Yamamoto Y, Motojima Y, Ueno H . Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist. J Physiol Sci. 2017; 68(2):129-136. PMC: 6394659. DOI: 10.1007/s12576-016-0517-5. View