Micelles with Ultralow Critical Micelle Concentration As Carriers for Drug Delivery

Overview

Journal Nat Biomed Eng

Publisher Springer Nature

Specialty Biomedical Engineering

Date 2019 Apr 3

PMID 30936455

Citations 64

Authors

Yang Lu

Zhanguo Yue

Jinbing Xie

Wei Wang

Hui Zhu

Ershuai Zhang

Zhiqiang Cao

Affiliations

Soon will be listed here.

Abstract

Conventional micellar carriers disassemble into free surfactants when diluted at concentrations below the critical micelle concentration (CMC). This limits the bioavailability in vivo of injected hydrophobic drugs encapsulated in micellar systems. Here, we show that a micelle comprising a superhydrophilic zwitterionic polymer domain and a superhydrophobic lipid domain has an undetectable CMC below 10 mM-a value that is orders of magnitude lower than the CMCs (>10 mM) of typical micellar systems. We also show that zwitterionic moieties or zwitterionic polymers added to a micelle solution stabilize the micelles at concentrations below their inherent CMC. In a mouse model of melanoma, ultralow-CMC micelles encapsulating docetaxel led to the complete eradication of tumours, whereas conventional docetaxel micellar formulations did not reverse tumour growth. Ultralow-CMC micelles might become next-generation carriers for drug delivery.

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