Spare Parts from Discarded Materials: Fetal Annexes in Regenerative Medicine

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2019 Apr 3

PMID 30934825

Citations 12

Authors

Giulia Gaggi

Pascal Izzicupo

Andrea Di Credico

Silvia Sancilio

Angela Di Baldassarre

Barbara Ghinassi

Affiliations

Soon will be listed here.

Abstract

One of the main aims in regenerative medicine is to find stem cells that are easy to obtain and are safe and efficient in either an autologous or allogenic host when transplanted. This review provides an overview of the potential use of the fetal annexes in regenerative medicine: we described the formation of the annexes, their immunological features, the new advances in the phenotypical characterization of fetal annexes-derived stem cells, the progressions obtained in the analysis of both their differentiative potential and their secretoma, and finally, the potential use of decellularized fetal membranes. Normally discarded as medical waste, the umbilical cord and perinatal tissue not only represent a rich source of stem cells but can also be used as a scaffold for regenerative medicine, providing a suitable environment for the growth and differentiation of stem cells.

Citing Articles

Exploring Potential Impact of Graphene Oxide and Graphene Oxide-Polyethylenimine on Biological Behavior of Human Amniotic Fluid-Derived Stem Cells.

Di Credico A, Gaggi G, Bibbo S, Pilato S, Moffa S, Di Giacomo S Int J Mol Sci. 2025; 25(24.

PMID: 39769359 PMC: 11678234. DOI: 10.3390/ijms252413598.

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease.

Yi L, Woon H, Saw G, Zeng L, Tan E, Zhou Z Neural Regen Res. 2024; 20(11):3193-3206.

PMID: 39665833 PMC: 11881713. DOI: 10.4103/NRR.NRR-D-24-00771.

Unraveling the Epigenetic Landscape: Insights into Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis.

Di Martino P, Marcozzi V, Bibbo S, Ghinassi B, Di Baldassarre A, Gaggi G Brain Sci. 2024; 14(6).

PMID: 38928553 PMC: 11202179. DOI: 10.3390/brainsci14060553.

The Effects of Combined Exposure to Bisphenols and Perfluoroalkyls on Human Perinatal Stem Cells and the Potential Implications for Health Outcomes.

Di Credico A, Gaggi G, Bucci I, Ghinassi B, Di Baldassarre A Int J Mol Sci. 2023; 24(19).

PMID: 37834465 PMC: 10573528. DOI: 10.3390/ijms241915018.

Human fetal membrane-mesenchymal stromal cells generate functional spinal motor neurons .

Gaggi G, Di Credico A, Guarnieri S, Mariggio M, Ballerini P, Di Baldassarre A iScience. 2022; 25(10):105197.

PMID: 36238899 PMC: 9550654. DOI: 10.1016/j.isci.2022.105197.

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