Effects of Thyroidectomy and Thyroxine Replacement on the Responsiveness of the Anterior Pituitaries from Male Rats to Thyrotropin-releasing Hormone in Vitro

Overview

Journal Experientia

Specialty Science

Date 1986 Sep 15

PMID 3093263

Authors

T K Tang

S W Wang

P S Wang

Affiliations

Soon will be listed here.

Abstract

Thyroidectomy decreased prolactin concentrations in the anterior pituitary (AP) and serum of the male rat. The amount of basal and thyrotropin-releasing hormone (TRH)-stimulated release of prolactin by AP in vitro was lower in thyroidectomized (Tx) rats than in sham Tx rats. These results suggest that the inhibitory effects of thyroidectomy on pituitary and serum prolactin in male rats are mediated in part by the reduction of the production and spontaneous release of prolactin and the responsiveness of prolactin to TRH.

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