Communication Between Mitochondria and Other Organelles: a Brand-new Perspective on Mitochondria in Cancer

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2019 Apr 2

PMID 30931098

Citations 84

Authors

Mengfang Xia

Yazhuo Zhang

Ke Jin

Zitong Lu

Zhaoyang Zeng

Wei Xiong

Affiliations

Soon will be listed here.

Abstract

Mitochondria are energy factories of cells and are important pivots for intracellular interactions with other organelles. They interact with the endoplasmic reticulum, peroxisomes, and nucleus through signal transduction, vesicle transport, and membrane contact sites to regulate energy metabolism, biosynthesis, immune response, and cell turnover. However, when the communication between organelles fails and the mitochondria are dysfunctional, it may induce tumorigenesis. In this review, we elaborate on how mitochondria interact with the endoplasmic reticulum, peroxisomes, and cell nuclei, as well as the relation between organelle communication and tumor development .

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