Changes in Oxidative Stress Levels During Two Weeks of Smoking Cessation Treatment and Their Association with Nutritional Characteristics in Japanese Smokers

Overview

Journal Exp Ther Med

Specialty Pathology

Date 2019 Apr 2

PMID 30930973

Citations 6

Authors

Shino Oba

Yohei Inaba

Tomoyuki Shibuya

Joji Oshima

Kuniaki Seyama

Toshihiro Kobayashi

Naoki Kunugita

Toshihiro Ino

Affiliations

Soon will be listed here.

Abstract

Although several experimental studies have reported that oxidative stress levels decrease during smoking cessation, how they change among general smokers has yet to be completely elucidated. In the present study, a total of 23 smokers who underwent smoking cessation treatment were observed for two-week changes in their levels of 8-OHdG and 8-isoprostane. Physical and nutritional characteristics were measured at the initial patient visit, and casual urine samples were collected at the initial visit and at a follow-up visit two weeks later. Oxidative stress was measured by a high performance liquid chromatography electrochemical detector, and the two-week difference in the levels of oxidative stress was assessed according to demographic and nutrient factors. Neither the urinary level of 8-OHdG nor that of 8-isoprostane decreased, although the cotinine level was decreased at two weeks. A Two-way repeated ANOVA revealed a significant interaction for fat intake by time for the change in the 8-OHdG level (P=0.03) and significant interactions for α-tocopherol intake (P=0.03), iron intake, and carbohydrate intake (P=0.03), all of which were time-dependent for the change in the 8-isoprostane level. The 8-OHdG level decreased among smokers with a high fat intake and was increased with a low fat intake. The 8-isoprostane levels were decreased among smokers with a high carbohydrate intake and increased with a low carbohydrate intake, decreased with a low iron intake and increased with a high iron intake and decreased with a low α-tocopherol intake and increased with a high α-tocopherol intake. Although the present study failed to observe a decrease in oxidative stress levels during the two-week smoking cessation period, we hypothesize that the intake levels of specific nutrients when initiating smoking cessation treatment may predict any subsequent changes in the oxidative stress levels.

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References

Kawakami N, TAKATSUKA N, Inaba S, Shimizu H . Development of a screening questionnaire for tobacco/nicotine dependence according to ICD-10, DSM-III-R, and DSM-IV. Addict Behav. 1999; 24(2):155-66. DOI: 10.1016/s0306-4603(98)00127-0. View

Roberts 2nd L, Morrow J . Products of the isoprostane pathway: unique bioactive compounds and markers of lipid peroxidation. Cell Mol Life Sci. 2002; 59(5):808-20. PMC: 11146127. DOI: 10.1007/s00018-002-8469-8. View

Block G, Dietrich M, Norkus E, Morrow J, Hudes M, Caan B . Factors associated with oxidative stress in human populations. Am J Epidemiol. 2002; 156(3):274-85. DOI: 10.1093/aje/kwf029. View

Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen H . Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis. 1992; 13(12):2241-7. DOI: 10.1093/carcin/13.12.2241. View

Davi G, Falco A, Patrono C . Determinants of F2-isoprostane biosynthesis and inhibition in man. Chem Phys Lipids. 2004; 128(1-2):149-63. DOI: 10.1016/j.chemphyslip.2003.10.001. View

Grassi G, Seravalle G, Calhoun D, Bolla G, Mancia G . Cigarette smoking and the adrenergic nervous system. Clin Exp Hypertens A. 1992; 14(1-2):251-60. DOI: 10.3109/10641969209036186. View

Kim I, Darwin W, Huestis M . Simultaneous determination of nicotine, cotinine, norcotinine, and trans-3'-hydroxycotinine in human oral fluid using solid phase extraction and gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2005; 814(2):233-40. DOI: 10.1016/j.jchromb.2004.10.034. View

Morita H, Ikeda H, Haramaki N, Eguchi H, Imaizumi T . Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers. J Am Coll Cardiol. 2005; 45(4):589-94. DOI: 10.1016/j.jacc.2004.10.061. View

Irie M, Tamae K, Iwamoto-Tanaka N, Kasai H . Occupational and lifestyle factors and urinary 8-hydroxydeoxyguanosine. Cancer Sci. 2005; 96(9):600-6. PMC: 11159759. DOI: 10.1111/j.1349-7006.2005.00083.x. View

10.

Thompson H, Heimendinger J, Sedlacek S, Haegele A, Diker A, ONeill C . 8-Isoprostane F2alpha excretion is reduced in women by increased vegetable and fruit intake. Am J Clin Nutr. 2005; 82(4):768-76. DOI: 10.1093/ajcn/82.4.768. View

11.

Mizoue T, Kasai H, Kubo T, Tokunaga S . Leanness, smoking, and enhanced oxidative DNA damage. Cancer Epidemiol Biomarkers Prev. 2006; 15(3):582-5. DOI: 10.1158/1055-9965.EPI-05-0658. View

12.

Palozza P, Serini S, Trombino S, Lauriola L, Ranelletti F, Calviello G . Dual role of beta-carotene in combination with cigarette smoke aqueous extract on the formation of mutagenic lipid peroxidation products in lung membranes: dependence on pO2. Carcinogenesis. 2006; 27(12):2383-91. DOI: 10.1093/carcin/bgl074. View

13.

Hodgson J, Ward N, Burke V, Beilin L, Puddey I . Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humans. J Nutr. 2007; 137(2):363-7. DOI: 10.1093/jn/137.2.363. View

14.

McAnulty S, McAnulty L, Nieman D, Morrow J, Dumke C, Utter A . Carbohydrate effect: hormone and oxidative changes. Int J Sports Med. 2007; 28(11):921-7. DOI: 10.1055/s-2007-964987. View

15.

Helmersson J, Arnlov J, Larsson A, Basu S . Low dietary intake of beta-carotene, alpha-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort. Br J Nutr. 2008; 101(12):1775-82. DOI: 10.1017/S0007114508147377. View

16.

Sakano N, Wang D, Takahashi N, Wang B, Sauriasari R, Kanbara S . Oxidative stress biomarkers and lifestyles in Japanese healthy people. J Clin Biochem Nutr. 2009; 44(2):185-95. PMC: 2654475. DOI: 10.3164/jcbn.08-252. View

17.

Tamae K, Kawai K, Yamasaki S, Kawanami K, Ikeda M, Takahashi K . Effect of age, smoking and other lifestyle factors on urinary 7-methylguanine and 8-hydroxydeoxyguanosine. Cancer Sci. 2009; 100(4):715-21. PMC: 11158129. DOI: 10.1111/j.1349-7006.2009.01088.x. View

18.

Hori A, Mizoue T, Kasai H, Kawai K, Matsushita Y, Nanri A . Body iron store as a predictor of oxidative DNA damage in healthy men and women. Cancer Sci. 2009; 101(2):517-22. PMC: 11158582. DOI: 10.1111/j.1349-7006.2009.01394.x. View

19.

Hopkins M, Fedirko V, Jones D, Terry P, Bostick R . Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial. Cancer Epidemiol Biomarkers Prev. 2010; 19(3):850-8. DOI: 10.1158/1055-9965.EPI-09-1052. View

20.

Yeon J, Suh Y, Kim S, Baik H, Sung C, Kim H . Evaluation of dietary factors in relation to the biomarkers of oxidative stress and inflammation in breast cancer risk. Nutrition. 2011; 27(9):912-8. DOI: 10.1016/j.nut.2010.10.012. View