Pancreatic Stellate Cells: A Rising Translational Physiology Star As a Potential Stem Cell Type for Beta Cell Neogenesis

Overview

Journal Front Physiol

Date 2019 Apr 2

PMID 30930789

Citations 18

Authors

Yunting Zhou

Bo Sun

Wei Li

Junming Zhou

Feng Gao

Xiaohang Wang

Min Cai

Zilin Sun

Affiliations

Soon will be listed here.

Abstract

The progressive decline and eventual loss of islet β-cell function underlies the pathophysiological mechanism of the development of both type 1 and type 2 diabetes mellitus. The recovery of functional β-cells is an important strategy for the prevention and treatment of diabetes. Based on similarities in developmental biology and anatomy, induction of differentiation of other types of pancreatic cells into β-cells is a promising avenue for future diabetes treatment. Pancreatic stellate cells (PSCs), which have attracted intense research interest due to their effects on tissue fibrosis over the last decade, express multiple stem cell markers and can differentiate into various cell types. In particular, PSCs can successfully differentiate into insulin- secreting cells and can contribute to tissue regeneration. In this article, we will brings together the main concepts of the translational physiology potential of PSCs that have emerged from work in the field and discuss possible ways to develop the future renewable source for clinical treatment of pancreatic diseases.

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