» Articles » PMID: 30920535

Peptide-Based Physical Gels Endowed with Thixotropic Behaviour

Overview
Journal Gels
Date 2019 Mar 29
PMID 30920535
Citations 11
Authors
Affiliations
Soon will be listed here.
Abstract

Thixotropy is one of the oldest documented rheological phenomenon in colloid science and may be defined as an increase of viscosity in a state of rest and a decrease of viscosity when submitted to a constant shearing stress. This behavior has been exploited in recent years to prepare injectable hydrogels for application in drug delivery systems. Thixotropic hydrogels may be profitably used in the field of regenerative medicine, which promotes tissue healing after injuries and diseases, as the molten hydrogel may be injected by syringe and then self-adapts in the space inside the injection site and recovers the solid form. We will focus our attention on the preparation, properties, and some applications of biocompatible thixotropic hydrogels.

Citing Articles

A Review on the Rheological Properties of Single Amino Acids and Short Dipeptide Gels.

Veloso S, Rosa M, Diaferia C, Fernandes C Gels. 2024; 10(8).

PMID: 39195036 PMC: 11354022. DOI: 10.3390/gels10080507.


Evolution of Hybrid Hydrogels: Next-Generation Biomaterials for Drug Delivery and Tissue Engineering.

Rana M, De la Hoz Siegler H Gels. 2024; 10(4).

PMID: 38667635 PMC: 11049329. DOI: 10.3390/gels10040216.


(-Alkyloxalamido)-Amino Acid Amides as the Superior Thixotropic Phase Selective Gelators of Petrol and Diesel Fuels.

Sijakovic Vujicic N, Makarevic J, Popovic J, Stefanic Z, Zinic M Gels. 2023; 9(11).

PMID: 37998942 PMC: 10670479. DOI: 10.3390/gels9110852.


Creation of Molecular Gel Materials Using Polyrotaxane-Derived Polymeric Organogelator.

Ohsedo Y, Shinoda T Gels. 2023; 9(9).

PMID: 37754411 PMC: 10529233. DOI: 10.3390/gels9090730.


Self-Healing Oxalamide Organogelators of Vegetable Oil.

Sijakovic Vujicic N, Sajko J, Brkljacic L, Radosevic P, Jeric I, Kurecic I Gels. 2023; 9(9).

PMID: 37754380 PMC: 10528235. DOI: 10.3390/gels9090699.


References
1.
Dawn A, Shiraki T, Haraguchi S, Tamaru S, Shinkai S . What kind of "soft materials" can we design from molecular gels?. Chem Asian J. 2010; 6(2):266-82. DOI: 10.1002/asia.201000217. View

2.
Shigemitsu H, Fujisaku T, Onogi S, Yoshii T, Ikeda M, Hamachi I . Preparation of supramolecular hydrogel-enzyme hybrids exhibiting biomolecule-responsive gel degradation. Nat Protoc. 2016; 11(9):1744-56. DOI: 10.1038/nprot.2016.099. View

3.
Tao K, Levin A, Adler-Abramovich L, Gazit E . Fmoc-modified amino acids and short peptides: simple bio-inspired building blocks for the fabrication of functional materials. Chem Soc Rev. 2016; 45(14):3935-53. DOI: 10.1039/c5cs00889a. View

4.
Mewis J, Wagner N . Thixotropy. Adv Colloid Interface Sci. 2008; 147-148:214-27. DOI: 10.1016/j.cis.2008.09.005. View

5.
Kumar V, Liu Q, Wickremasinghe N, Shi S, Cornwright T, Deng Y . Treatment of hind limb ischemia using angiogenic peptide nanofibers. Biomaterials. 2016; 98:113-9. PMC: 4905688. DOI: 10.1016/j.biomaterials.2016.04.032. View