The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome

Overview

Journal Genet Med

Publisher Elsevier

Specialty Genetics

Date 2019 Mar 29

PMID 30918358

Citations 92

Authors

Emma J Crosbie

Neil A J Ryan

Mark J Arends

Tjalling Bosse

John Burn

Joanna M Cornes

Robin Crawford

Diana Eccles

Ian M Frayling

Sadaf Ghaem-Maghami

Heather Hampel

Noah D Kauff

Henry C Kitchener

Sarah J Kitson

Ranjit Manchanda

Raymond F T McMahon

Kevin J Monahan

Usha Menon

Pal Moller

Gabriela Moslein

Adam Rosenthal

Peter Sasieni

Mourad W Seif

Naveena Singh

Pauline Skarrott

Tristan M Snowsill

Robert Steele

Marc Tischkowitz

D Gareth Evans

Affiliations

Soon will be listed here.

Abstract

Purpose: There are no internationally agreed upon clinical guidelines as to which women with gynecological cancer would benefit from Lynch syndrome screening or how best to manage the risk of gynecological cancer in women with Lynch syndrome. The Manchester International Consensus Group was convened in April 2017 to address this unmet need. The aim of the Group was to develop clear and comprehensive clinical guidance regarding the management of the gynecological sequelae of Lynch syndrome based on existing evidence and expert opinion from medical professionals and patients.

Methods: Stakeholders from Europe and North America worked together over a two-day workshop to achieve consensus on best practice.

Results: Guidance was developed in four key areas: (1) whether women with gynecological cancer should be screened for Lynch syndrome and (2) how this should be done, (3) whether there was a role for gynecological surveillance in women at risk of Lynch syndrome, and (4) what preventive measures should be recommended for women with Lynch syndrome to reduce their risk of gynecological cancer.

Conclusion: This document provides comprehensive clinical guidance that can be referenced by both patients and clinicians so that women with Lynch syndrome can expect and receive appropriate standards of care.

Citing Articles

The English National Lynch Syndrome transformation project: an NHS Genomic Medicine Service Alliance (GMSA) programme.

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Lynch Syndrome-Impact of the Type of Deficient Mismatch Repair Gene Mutation on Diagnosis, Clinical Presentation, Surveillance and Therapeutic Approaches.

Grigorie T, Potlog G, Alexandrescu S Medicina (Kaunas). 2025; 61(1).

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Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the Netherlands.

Eikenboom E, van Leeuwen L, Groenendijk F, Woolderink J, Van Altena A, van Leerdam M EClinicalMedicine. 2025; 79():103006.

PMID: 39816931 PMC: 11733057. DOI: 10.1016/j.eclinm.2024.103006.

Gynecological Insights into Lynch Syndrome-A Comprehensive Review of Cancer Screening and Prevention.

Chitoran E, Bohiltea R, Rotaru V, Durdu C, Mitroiu M, Simion L Medicina (Kaunas). 2025; 60(12.

PMID: 39768893 PMC: 11728026. DOI: 10.3390/medicina60122013.

Detection of Mismatch Repair Deficiency in Endometrial Cancer: Assessment of IHC, Fragment Length Analysis, and Amplicon Sequencing Based MSI Testing.

Sowter P, Gallon R, Hayes C, Phelps R, Borthwick G, Prior S Cancers (Basel). 2024; 16(23).

PMID: 39682157 PMC: 11640224. DOI: 10.3390/cancers16233970.

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