Environmental Safety During the Administration of Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC)

Overview

Journal Pleura Peritoneum

Date 2019 Mar 27

PMID 30911624

Citations 21

Authors

Martin Graversen

Peter B Pedersen

Michael B Mortensen

Affiliations

Soon will be listed here.

Abstract

Background: Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) is an innovative technique for intraperitoneal drug delivery. This study investigates the efficacy of the occupational health safety measures taken to prevent exposition of healthcare workers to the toxic chemotherapy aerosol.

Methods: Air samples were taken at the working place of the surgeon and of the anesthetist during 2 PIPAC procedures and analyzed for content of platinum by inductively coupled plasma mass spectrometry (ICP-MS). Airborne particles were quantified in real time. Biological monitoring was performed in two surgeons after 50 PIPAC by examining blood samples for possible traces of platinum. Analysis was performed by an independent company.

Results: Safety measures included tightly closed abdomen, operating room (OR), ventilation meeting requirements of ISO norm 14644-1 class 5, closed aerosol waste system and remote control of PIPAC administration. No traces of platinum were found in the air of the OR (detection limit of 0.0001 mg/filter). No specific rise in particle concentration was detected in the air during the PIPAC procedure, patient closure and removal of the sterile drapes. Blood samples of the surgeons showed no traces of platinum.

Conclusions: After implementation of adequate safety measures, no signs of environmental contamination or biological exposure of the surgeons were detected during PIPAC.

Citing Articles

Implementation and evaluation of Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) for the treatment of patients with malignant pleural effusion: study protocol for the Danish phase-I PITAC-OPC5 study.

Hansen P, Graversen M, Detlefsen S, Ainsworth A, Fristrup C, Eckhoff L Pleura Peritoneum. 2024; 9(4):141-148.

PMID: 39712295 PMC: 11661466. DOI: 10.1515/pp-2024-0014.

Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) directed therapy of patients with malignant pleural effusion and pleural metastasis.

Hansen P, Graversen M, Detlefsen S, Ainsworth A, Mortensen M Pleura Peritoneum. 2024; 9(4):131-139.

PMID: 39712292 PMC: 11661464. DOI: 10.1515/pp-2024-0008.

Review on treatment of pleural metastasis and malignant pleural effusion with Pressurized IntraThoracic Aerosol Chemotherapy (PITAC).

Hansen P, Graversen M, Detlefsen S, Mortensen M Pleura Peritoneum. 2024; 9(2):47-53.

PMID: 38948327 PMC: 11211649. DOI: 10.1515/pp-2023-0048.

Airborne and surface contamination after rotational intraperitoneal pressurized aerosol chemotherapy using cisplatin.

Jung W, Park M, Park S, Lee E, Kim H, Kim S J Gynecol Oncol. 2024; 36(1):e12.

PMID: 38872481 PMC: 11791003. DOI: 10.3802/jgo.2025.36.e12.

Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model.

Jung W, Park M, Park S, Lee E, Kim H, Chung S Saf Health Work. 2023; 14(2):237-242.

PMID: 37389318 PMC: 10300457. DOI: 10.1016/j.shaw.2023.04.002.

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