Function and Dysfunction of Plasma Cells in Intestine

Overview

Journal Cell Biosci

Publisher Biomed Central

Specialty Biology

Date 2019 Mar 27

PMID 30911371

Citations 7

Authors

Xue Wang

Gui-Liang Hao

Bo-Ya Wang

Chen-Chen Gao

Yue-Xiu Wang

Li-Sheng Li

Jing-Dong Xu

Affiliations

Soon will be listed here.

Abstract

As the main player in humoral immunity, antibodies play indispensable roles in the body's immune system. Plasma cells (PCs), as antibody factories, are important contributors to humoral immunity. PCs, recognized by their unique marker CD138, are always discovered in the medullary cords of spleen and lymph nodes and in bone marrow and mucosal lymphoid tissue. This article will review the origin and differentiation of PCs, characteristics of short- and long-lived PCs, and the secretion of antibodies, such as IgA, IgM, and IgG. PCs play a crucial role in the maintenance of intestinal homeostasis using immunomodulation though complex mechanisms. Clearly, PCs play functional roles in maintaining intestinal health, but more details are needed to fully understand all the other effects of intestinal PCs.

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