Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression

Overview

Journal Int J Med Sci

Specialty General Medicine

Date 2019 Mar 27

PMID 30911276

Citations 6

Authors

Motona Kumagai

Xin Guo

Ke-Yong Wang

Hiroto Izumi

Manabu Tsukamoto

Tamiji Nakashima

Takashi Tasaki

Nozomu Kurose

Hidetaka Uramoto

Yasuyuki Sasaguri

Kimitoshi Kohno

Sohsuke Yamada

Affiliations

Soon will be listed here.

Abstract

: We recently reported that WNT10A plays a pivotal role in wound healing by regulating collagen expression/synthesis, as the depletion of WNT10A dramatically delays skin ulcer formation. WNT signaling also has a close correlation with the cancer microenvironment and proliferation, since tumors are actually considered to be 'unhealing' or 'overhealing' wounds. To ascertain the regulatory functions of WNT10A in tumor growth, we examined the net effects of WNT10A depletion using -deficient mice ( ). : We subjected C57BL/6J wild-type (WT) or mice to murine melanoma B16-F10 cell transplantation. mice showed a significantly smaller volume of transplanted melanoma as well as fewer microvessels and less collagen expression and more necrosis than WT mice. : Taken together, our observations suggest that critical roles of -depleted anti-stromagenesis prevent tumor growth, in contrast with true wound healing/scarring.

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