Future Directions for Understanding Adolescent Bipolar Spectrum Disorders: A Reward Hypersensitivity Perspective

Overview

Journal J Clin Child Adolesc Psychol

Publisher Routledge

Specialties Pediatrics
Psychology

Date 2019 Mar 26

PMID 30908092

Citations 15

Authors

Lauren B Alloy

Robin Nusslock

Affiliations

Soon will be listed here.

Abstract

The idea that bipolar spectrum disorders (BSDs) are characterized by enhanced sensitivity to rewarding stimuli is at the core of the reward hypersensitivity model, one of the most prominent and well-supported theories of BSDs. In this article, we present the reward hypersensitivity model of BSDs, review evidence supporting it, discuss its relevance to explaining why BSDs typically begin and consolidate during the period of adolescence, and consider three major unresolved issues for this model that provide important directions for future research. Finally, we present integrations of the reward hypersensitivity model with circadian rhythm and immune system models that should provide greater understanding of the mechanisms involved in BSDs, and then suggest additional directions for future research deriving from these integrated models.

Citing Articles

Illuminating Hypomania in Early Adolescence: Associations Between Dark-Side and Bright-Side Hypomania, Insomnia, and Health-Related Quality of Life.

Eisenhut L, Sadeghi-Bahmani D, Dursteler K, Mikoteit T, Fichter C, Bruhl A J Clin Med. 2024; 13(22).

PMID: 39597929 PMC: 11594785. DOI: 10.3390/jcm13226785.

The path from mood symptoms to substance use: A longitudinal examination in individuals with and at risk for bipolar spectrum disorders.

Smith L, Bishop O, Nusslock R, Alloy L J Affect Disord. 2024; 360:33-41.

PMID: 38815758 PMC: 11185173. DOI: 10.1016/j.jad.2024.05.146.

Neurocognitive risk phenotyping to predict mood symptoms in adolescence.

Kaiser R, Moser A, Neilson C, Jones J, Peterson E, Ruzic L J Psychopathol Clin Sci. 2023; 133(1):90-102.

PMID: 38059934 PMC: 10752243. DOI: 10.1037/abn0000866.

Reward sensitivity and social rhythms during goal-striving: An ecological momentary assessment investigation of bipolar spectrum disorders.

Walsh R, Klugman J, Moriarity D, Titone M, Ng T, Goel N J Affect Disord. 2023; 344:510-518.

PMID: 37852584 PMC: 10842638. DOI: 10.1016/j.jad.2023.10.114.

Cumulative lifetime acute stressor exposure interacts with reward responsiveness to predict longitudinal increases in depression severity in adolescence.

Burani K, Brush C, Shields G, Klein D, Nelson B, Slavich G Psychol Med. 2023; 53(10):4507-4516.

PMID: 37698514 PMC: 10388334. DOI: 10.1017/S0033291722001386.

References

Roenneberg T, Merrow M . Entrainment of the human circadian clock. Cold Spring Harb Symp Quant Biol. 2008; 72:293-9. DOI: 10.1101/sqb.2007.72.043. View

Grandin L, Alloy L, Abramson L . The social zeitgeber theory, circadian rhythms, and mood disorders: review and evaluation. Clin Psychol Rev. 2006; 26(6):679-94. DOI: 10.1016/j.cpr.2006.07.001. View

Sleipness E, Sorg B, Jansen H . Diurnal differences in dopamine transporter and tyrosine hydroxylase levels in rat brain: dependence on the suprachiasmatic nucleus. Brain Res. 2006; 1129(1):34-42. DOI: 10.1016/j.brainres.2006.10.063. View

Merikangas K, Akiskal H, Angst J, Greenberg P, Hirschfeld R, Petukhova M . Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication. Arch Gen Psychiatry. 2007; 64(5):543-52. PMC: 1931566. DOI: 10.1001/archpsyc.64.5.543. View

Irwin M, Eisenberger N . Context-Dependent Effects of Inflammation: Reduced Reward Responding is Not an Invariant Outcome of Sickness. Neuropsychopharmacology. 2016; 42(4):785-786. PMC: 5312070. DOI: 10.1038/npp.2016.245. View

Thomas D, Apovian C . Macrophage functions in lean and obese adipose tissue. Metabolism. 2017; 72:120-143. PMC: 5516622. DOI: 10.1016/j.metabol.2017.04.005. View

Knutson K . The association between pubertal status and sleep duration and quality among a nationally representative sample of U. S. adolescents. Am J Hum Biol. 2005; 17(4):418-24. DOI: 10.1002/ajhb.20405. View

Harmon-Jones E, Abramson L, Sigelman J, Bohlig A, Hogan M, Harmon-Jones C . Proneness to hypomania/mania symptoms or depression symptoms and asymmetrical frontal cortical responses to an anger-evoking event. J Pers Soc Psychol. 2002; 82(4):610-8. View

Romer A, Reyna V, Pardo S . Are rash impulsive and reward sensitive traits distinguishable? A test in young adults. Pers Individ Dif. 2017; 99:308-312. PMC: 5573241. DOI: 10.1016/j.paid.2016.05.027. View

10.

Murray G, Nicholas C, Kleiman J, Dwyer R, Carrington M, Allen N . Nature's clocks and human mood: the circadian system modulates reward motivation. Emotion. 2009; 9(5):705-16. DOI: 10.1037/a0017080. View

11.

VAN Meter A, Moreira A, Youngstrom E . Meta-analysis of epidemiologic studies of pediatric bipolar disorder. J Clin Psychiatry. 2011; 72(9):1250-6. DOI: 10.4088/JCP.10m06290. View

12.

Haber S, Knutson B . The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2009; 35(1):4-26. PMC: 3055449. DOI: 10.1038/npp.2009.129. View

13.

Alloy L, Abramson L, Walshaw P, Keyser J, Gerstein R . A cognitive vulnerability-stress perspective on bipolar spectrum disorders in a normative adolescent brain, cognitive, and emotional development context. Dev Psychopathol. 2006; 18(4):1055-103. DOI: 10.1017/S0954579406060524. View

14.

Carskadon M . Sleep in adolescents: the perfect storm. Pediatr Clin North Am. 2011; 58(3):637-47. PMC: 3130594. DOI: 10.1016/j.pcl.2011.03.003. View

15.

Frank E, Kupfer D, Thase M, Mallinger A, Swartz H, Fagiolini A . Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder. Arch Gen Psychiatry. 2005; 62(9):996-1004. DOI: 10.1001/archpsyc.62.9.996. View

16.

Forbes E, Dahl R . Research Review: altered reward function in adolescent depression: what, when and how?. J Child Psychol Psychiatry. 2011; 53(1):3-15. PMC: 3232324. DOI: 10.1111/j.1469-7610.2011.02477.x. View

17.

Harmon-Jones E . Early Career Award. Clarifying the emotive functions of asymmetrical frontal cortical activity. Psychophysiology. 2004; 40(6):838-48. DOI: 10.1111/1469-8986.00121. View

18.

Forbes E, Dahl R, Almeida J, Ferrell R, Nimgaonkar V, Mansour H . PER2 rs2304672 polymorphism moderates circadian-relevant reward circuitry activity in adolescents. Biol Psychiatry. 2011; 71(5):451-7. PMC: 3323120. DOI: 10.1016/j.biopsych.2011.10.012. View

19.

Cuellar A, Johnson S, Winters R . Distinctions between bipolar and unipolar depression. Clin Psychol Rev. 2005; 25(3):307-39. PMC: 2850601. DOI: 10.1016/j.cpr.2004.12.002. View

20.

Mistlberger R, Skene D . Social influences on mammalian circadian rhythms: animal and human studies. Biol Rev Camb Philos Soc. 2004; 79(3):533-56. DOI: 10.1017/s1464793103006353. View