The Metabolic Modulator PGC-1α in Cancer

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2019 Mar 26

PMID 30906622

Citations 95

Authors

Frederic Bost

Lisa Kaminski

Affiliations

Soon will be listed here.

Abstract

The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles have shown that PGC-1α expression is altered in tumors and metastasis in relation to modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target and a biomarker of the advanced form of cancer will be summarized in this review.

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