Activation and Counteraction of Antiviral Innate Immunity by KSHV: an Update

Overview

Journal Sci Bull (Beijing)

Specialty Science

Date 2019 Mar 26

PMID 30906617

Citations 6

Authors

Xiaoqin Wei

Ke Lan

Affiliations

Soon will be listed here.

Abstract

The innate immune responses triggering production of type I interferons and inflammatory cytokines constitute a nonspecific innate resistance that eliminates invading pathogens including viruses. The activation of innate immune signaling through pattern recognition receptors (PRRs) is by sensing pathogen-associated molecular patterns derived from viruses. According to their distribution within cells, PRRs are classified into three types of receptors: membrane, cytoplasmic, and nuclear. Kaposi's sarcoma-associated herpesvirus (KSHV), a large DNA virus, replicates in the nucleus. Its genome is protected by capsid proteins during transport in the cytosol. Multiple PRRs are involved in KSHV recognition. To successfully establish latent infection, KSHV has evolved to manipulate different aspects of the host antiviral innate immune responses. This review presents recent advances in our understanding about the activation of the innate immune signaling in response to infection of KSHV. It also reviews the evasion strategies used by KSHV to subvert host innate immune detection for establishing a persistent infection.

Citing Articles

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References

Ballestas M, Chatis P, Kaye K . Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen. Science. 1999; 284(5414):641-4. DOI: 10.1126/science.284.5414.641. View

Neipel F, Fleckenstein B . The role of HHV-8 in Kaposi's sarcoma. Semin Cancer Biol. 1999; 9(3):151-64. DOI: 10.1006/scbi.1999.0129. View

Lukac D, Kirshner J, Ganem D . Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol. 1999; 73(11):9348-61. PMC: 112969. DOI: 10.1128/JVI.73.11.9348-9361.1999. View

Baghian A, Luftig M, Black J, Meng Y, Pau C, Voss T . Glycoprotein B of human herpesvirus 8 is a component of the virion in a cleaved form composed of amino- and carboxyl-terminal fragments. Virology. 2000; 269(1):18-25. DOI: 10.1006/viro.2000.0198. View

Rehli M, Poltorak A, Schwarzfischer L, Krause S, Andreesen R, Beutler B . PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J Biol Chem. 2000; 275(13):9773-81. DOI: 10.1074/jbc.275.13.9773. View

Seckin D, Demirag A, Hizel N, Demirhan B, Erdal R . Absence of Epstein-Barr virus DNA sequences in iatrogenic Kaposi's sarcomas of renal transplant recipients. Transplant Proc. 2000; 32(3):554-5. DOI: 10.1016/s0041-1345(00)00887-3. View

Wu L, Lo P, Yu X, STOOPS J, Forghani B, Zhou Z . Three-dimensional structure of the human herpesvirus 8 capsid. J Virol. 2000; 74(20):9646-54. PMC: 112397. DOI: 10.1128/jvi.74.20.9646-9654.2000. View

Deng H, Young A, Sun R . Auto-activation of the rta gene of human herpesvirus-8/Kaposi's sarcoma-associated herpesvirus. J Gen Virol. 2000; 81(Pt 12):3043-3048. DOI: 10.1099/0022-1317-81-12-3043. View

Jenner R, Alba M, Boshoff C, Kellam P . Kaposi's sarcoma-associated herpesvirus latent and lytic gene expression as revealed by DNA arrays. J Virol. 2001; 75(2):891-902. PMC: 113985. DOI: 10.1128/JVI.75.2.891-902.2001. View

10.

Nealon K, Newcomb W, Pray T, Craik C, Brown J, Kedes D . Lytic replication of Kaposi's sarcoma-associated herpesvirus results in the formation of multiple capsid species: isolation and molecular characterization of A, B, and C capsids from a gammaherpesvirus. J Virol. 2001; 75(6):2866-78. PMC: 115913. DOI: 10.1128/JVI.75.6.2866-2878.2001. View

11.

Lin R, Genin P, Mamane Y, Sgarbanti M, Battistini A, Harrington Jr W . HHV-8 encoded vIRF-1 represses the interferon antiviral response by blocking IRF-3 recruitment of the CBP/p300 coactivators. Oncogene. 2001; 20(7):800-11. DOI: 10.1038/sj.onc.1204163. View

12.

Akula S, Pramod N, Wang F, Chandran B . Human herpesvirus 8 envelope-associated glycoprotein B interacts with heparan sulfate-like moieties. Virology. 2001; 284(2):235-49. DOI: 10.1006/viro.2001.0921. View

13.

Wang F, Akula S, Pramod N, Zeng L, Chandran B . Human herpesvirus 8 envelope glycoprotein K8.1A interaction with the target cells involves heparan sulfate. J Virol. 2001; 75(16):7517-27. PMC: 114987. DOI: 10.1128/JVI.75.16.7517-7527.2001. View

14.

Haynes L, Moore D, Finberg R, Anderson L, Tripp R . Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus. J Virol. 2001; 75(22):10730-7. PMC: 114654. DOI: 10.1128/JVI.75.22.10730-10737.2001. View

15.

Rassa J, Meyers J, Zhang Y, Kudaravalli R, Ross S . Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci U S A. 2002; 99(4):2281-6. PMC: 122356. DOI: 10.1073/pnas.042355399. View

16.

Naranatt P, Akula S, Chandran B . Characterization of gamma2-human herpesvirus-8 glycoproteins gH and gL. Arch Virol. 2002; 147(7):1349-70. DOI: 10.1007/s00705-002-0813-7. View

17.

Hengge U, Ruzicka T, Tyring S, Stuschke M, Roggendorf M, Schwartz R . Update on Kaposi's sarcoma and other HHV8 associated diseases. Part 2: pathogenesis, Castleman's disease, and pleural effusion lymphoma. Lancet Infect Dis. 2002; 2(6):344-52. DOI: 10.1016/s1473-3099(02)00288-8. View

18.

Koyano S, Mar E, Stamey F, Inoue N . Glycoproteins M and N of human herpesvirus 8 form a complex and inhibit cell fusion. J Gen Virol. 2003; 84(Pt 6):1485-1491. DOI: 10.1099/vir.0.18941-0. View

19.

Boulanger E, Daniel M, Agbalika F, Oksenhendler E . Combined chemotherapy including high-dose methotrexate in KSHV/HHV8-associated primary effusion lymphoma. Am J Hematol. 2003; 73(3):143-8. DOI: 10.1002/ajh.10341. View

20.

Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H . Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 2003; 301(5633):640-3. DOI: 10.1126/science.1087262. View