Recent Advances in Understanding Phosphoinositide Signaling in the Nervous System

Overview

Journal F1000Res

Specialties Biomedical Engineering
Science

Date 2019 Mar 26

PMID 30906529

Citations 8

Authors

Eamonn James Dickson

Affiliations

Soon will be listed here.

Abstract

Polyphosphoinositides (PPIn) are essential signaling phospholipids that make remarkable contributions to the identity of all cellular membranes and signaling cascades in mammalian cells. They exert regulatory control over membrane homeostasis via selective interactions with cellular proteins at the membrane-cytoplasm interface. This review article briefly summarizes our current understanding of the key roles that PPIn play in orchestrating and regulating crucial electrical and chemical signaling events in mammalian neurons and the significant neuro-pathophysiological conditions that arise following alterations in their metabolism.

Citing Articles

Chemical Synthesis of 6-Azido-6-Deoxy Derivatives of Phosphatidylinositol Containing Different Fatty Acid Chains.

Molla M, Gupta P, Rohokale R, Guo Z Molecules. 2024; 29(21).

PMID: 39519623 PMC: 11547759. DOI: 10.3390/molecules29214981.

Desorption Electrospray Ionization Cyclic Ion Mobility-Mass Spectrometry Imaging for Traumatic Brain Injury Spatial Metabolomics.

Leontyev D, Olivos H, Shrestha B, Datta Roy P, LaPlaca M, Fernandez F Anal Chem. 2024; 96(33):13598-13606.

PMID: 39106040 PMC: 11339727. DOI: 10.1021/acs.analchem.4c02394.

Assessing the associations of 1,400 blood metabolites with major depressive disorder: a Mendelian randomization study.

Dong T, Wang X, Jia Z, Yang J, Liu Y Front Psychiatry. 2024; 15:1391535.

PMID: 38903637 PMC: 11187323. DOI: 10.3389/fpsyt.2024.1391535.

First insights into the honey bee () brain lipidome and its neonicotinoid-induced alterations associated with reduced self-grooming behavior.

Morfin N, Fillier T, Pham T, Goodwin P, Thomas R, Guzman-Novoa E J Adv Res. 2022; 37:75-89.

PMID: 35499051 PMC: 9039751. DOI: 10.1016/j.jare.2021.08.007.

Phosphoinositide transport and metabolism at membrane contact sites.

Dickson E Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(3):159107.

PMID: 34995791 PMC: 9662651. DOI: 10.1016/j.bbalip.2021.159107.

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