Measures of Central Sensitisation and Their Measurement Properties in the Adult Musculoskeletal Trauma Population: a Protocol for a Systematic Review and Data Synthesis

Overview

Journal BMJ Open

Specialty General Medicine

Date 2019 Mar 25

PMID 30904837

Citations 4

Authors

Nicola Middlebrook

Alison B Rushton

Nicola R Heneghan

Deborah Falla

Affiliations

Soon will be listed here.

Abstract

Introduction: Pain following musculoskeletal trauma is common with poor outcomes and disability well documented. Pain is complex in nature and can include the four primary mechanisms of pain: nociceptive, neuropathic, inflammatory and central sensitisation (CS). CS can be measured in multiple ways; however, no systematic review has evaluated the measurement properties of such measures in the musculoskeletal trauma population. This systematic review aims to evaluate the measurement properties of current measures of CS in this population.

Methods/analysis: This protocol is informed and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P. MEDLINE, EMBASE, CINAHL, ZETOC, Web of Science, PubMed and Google Scholar as well as key journals and grey literature will be searched in two stages to (1) identify what measures are being used to assess CS in this population and (2) evaluate the measurement properties of the identified measures. Two independent reviewers will conduct the search, extract the data, assess risk of bias for included studies and assess overall quality. The Consensus-based Standards for the selection of Health Measurement Instruments Risk of Bias Checklist and a modified Grading of Recommendations, Assessment, Development and Evaluation guidelines will be used. Meta-analysis will be conducted if deemed appropriate. Alternatively, a narrative synthesis will be conducted and summarised per measurement property per outcome measure.

Ethics And Dissemination: This review will aid clinicians in using the most appropriate tool for assessing central sensitisation in this population and is the first step towards a more standardised approach in pain assessment. The results of this study will be submitted to a peer reviewed journal and presented at conferences.

Prospero Registrationnumber: CRD42018091531.

Citing Articles

The role of post-trauma stress symptoms in the development of chronic musculoskeletal pain and disability: A systematic review.

Jadhakhan F, Evans D, Falla D Eur J Pain. 2022; 27(2):183-200.

PMID: 36317593 PMC: 10099552. DOI: 10.1002/ejp.2048.

The Definition, Assessment, and Prevalence of (Human Assumed) Central Sensitisation in Patients with Chronic Low Back Pain: A Systematic Review.

Schuttert I, Timmerman H, Petersen K, McPhee M, Arendt-Nielsen L, Reneman M J Clin Med. 2021; 10(24).

PMID: 34945226 PMC: 8703986. DOI: 10.3390/jcm10245931.

Successful recovery following musculoskeletal trauma: protocol for a qualitative study of patients' and physiotherapists' perceptions.

Middlebrook N, Heneghan N, Falla D, Silvester L, Rushton A, Soundy A BMC Musculoskelet Disord. 2021; 22(1):163.

PMID: 33568110 PMC: 7874566. DOI: 10.1186/s12891-021-04035-9.

Reliability of temporal summation, thermal and pressure pain thresholds in a healthy cohort and musculoskeletal trauma population.

Middlebrook N, Heneghan N, Evans D, Rushton A, Falla D PLoS One. 2020; 15(5):e0233521.

PMID: 32469913 PMC: 7259760. DOI: 10.1371/journal.pone.0233521.

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