Electrophysiological Differences Between Upper and Lower Limb Movements in the Human Subthalamic Nucleus

Overview

Journal Clin Neurophysiol

Publisher Elsevier

Specialties Neurology
Psychiatry

Date 2019 Mar 24

PMID 30903826

Citations 17

Authors

Gerd Tinkhauser

Syed Ahmar Shah

Petra Fischer

Katrin Peterman

Ines Debove

Khoa Nygyuen

Andreas Nowacki

Flavie Torrecillos

Saed Khawaldeh

Huiling Tan

Alek Pogosyan

Michael Schuepbach

Claudio Pollo

Peter Brown

Affiliations

Soon will be listed here.

Abstract

Objective: Functional processes in the brain are segregated in both the spatial and spectral domain. Motivated by findings reported at the cortical level in healthy participants we test the hypothesis in the basal ganglia of Parkinson's disease patients that lower frequency beta band activity relates to motor circuits associated with the upper limb and higher beta frequencies with lower limb movements.

Methods: We recorded local field potentials (LFPs) from the subthalamic nucleus using segmented "directional" DBS leads, during which patients performed repetitive upper and lower limb movements. Movement-related spectral changes in the beta and gamma frequency-ranges and their spatial distributions were compared between limbs.

Results: We found that the beta desynchronization during leg movements is characterised by a strikingly greater involvement of higher beta frequencies (24-31 Hz), regardless of whether this was contralateral or ipsilateral to the limb moved. The spatial distribution of limb-specific movement-related changes was evident at higher gamma frequencies.

Conclusion: Limb processing in the basal ganglia is differentially organised in the spectral and spatial domain and can be captured by directional DBS leads.

Significance: These findings may help to refine the use of the subthalamic LFPs as a control signal for adaptive DBS and neuroprosthetic devices.

Citing Articles

Subthalamic stimulation modulates context-dependent effects of beta bursts during fine motor control.

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Clinical neurophysiological interrogation of motor slowing: A critical step towards tuning adaptive deep brain stimulation.

Alva L, Bernasconi E, Torrecillos F, Fischer P, Averna A, Bange M Clin Neurophysiol. 2023; 152:43-56.

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Spectral Topography of the Subthalamic Nucleus to Inform Next-Generation Deep Brain Stimulation.

Averna A, Debove I, Nowacki A, Peterman K, Duchet B, Sousa M Mov Disord. 2023; 38(5):818-830.

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Subthalamic and nigral neurons are differentially modulated during parkinsonian gait.

Gulberti A, Wagner J, Horn M, Reuss J, Heise M, Koeppen J Brain. 2023; 146(7):2766-2779.

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Cometa A, Falasconi A, Biasizzo M, Carpaneto J, Horn A, Mazzoni A iScience. 2022; 25(10):105124.

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