Comparative Genomics Reveals the Genetic Mechanisms of Musk Secretion and Adaptive Immunity in Chinese Forest Musk Deer

Overview

Journal Genome Biol Evol

Publisher Oxford University Press

Specialties Biology
Genetics
Molecular Biology

Date 2019 Mar 24

PMID 30903183

Citations 10

Authors

Chuang Zhou

Wenbo Zhang

Qinchao Wen

Ping Bu

Jie Gao

Guannan Wang

Jiazheng Jin

Yinjie Song

Xiaohong Sun

Yifan Zhang

Xue Jiang

Haoran Yu

Changjun Peng

Yongmei Shen

Megan Price

Jing Li

Xiuyue Zhang

Zhenxin Fan

Bisong Yue

Affiliations

Soon will be listed here.

Abstract

The Chinese forest musk deer (Moschus berezovskii; FMD) is an artiodactyl mammal and is both economically valuable and highly endangered. To investigate the genetic mechanisms of musk secretion and adaptive immunity in FMD, we compared its genome to nine other artiodactyl genomes. Comparative genomics demonstrated that eight positively selected genes (PSGs) in FMD were annotated in three KEGG pathways that were related to metabolic and synthetic activity of musk, similar to previous transcriptome studies. Functional enrichment analysis indicated that many PSGs were involved in the regulation of immune system processes, implying important reorganization of the immune system in FMD. FMD-specific missense mutations were found in two PSGs (MHC class II antigen DRA and ADA) that were classified as deleterious by PolyPhen-2, possibly contributing to immune adaptation to infectious diseases. Functional assessment showed that the FMD-specific mutation enhanced the ADA activity, which was likely to strengthen the immune defense against pathogenic invasion. Single nucleotide polymorphism-based inference showed the recent demographic trajectory for FMD. Our data and findings provide valuable genomic resources not only for studying the genetic mechanisms of musk secretion and adaptive immunity, but also for facilitating more effective management of the captive breeding programs for this endangered species.

Citing Articles

Analysis and comparison of blood metabolome of forest musk deer in musk secretion and non-secretion periods.

Wang Y, Yang P, Chen T, Hu J, An X, Yao C Sci Rep. 2024; 14(1):16980.

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Integrated multi-omics analysis reveals insights into Chinese forest musk deer () genome evolution and musk synthesis.

Feng H, Feng T, Mo Y, Sun S, Wang L, Lu C Front Cell Dev Biol. 2023; 11:1156138.

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Comparative analysis of gut microbial composition and potential functions in captive forest and alpine musk deer.

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