Impact of Nutritional Changes on Nonalcoholic Fatty Liver Disease

Overview

Journal Nutrients

Date 2019 Mar 24

PMID 30901929

Citations 79

Authors

Carolina M Perdomo

Gema Fruhbeck

Javier Escalada

Affiliations

Soon will be listed here.

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a major global health threat due to its growing incidence and prevalence. It is becoming the leading cause of liver disease in addition to its strong association with cardio-metabolic disease. Therefore, its prevention and treatment are of strong public interest. Therapeutic approaches emphasize lifestyle modifications including physical activity and the adoption of healthy eating habits that intend to mainly control body weight and cardio-metabolic risk factors associated with the metabolic syndrome. Lifestyle interventions may be reinforced by pharmacological treatment in advanced stages, though there is still no registered drug for the specific treatment of NAFLD. The purpose of this review is to assess the evidence available regarding the impact of dietary recommendations against NAFLD, highlighting the effect of macronutrient diet composition and dietary patterns in the management of NAFLD.

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References

Gomez-Ambrosi J, Salvador J, Paramo J, Orbe J, de Irala J, Diez-Caballero A . Involvement of leptin in the association between percentage of body fat and cardiovascular risk factors. Clin Biochem. 2002; 35(4):315-20. DOI: 10.1016/s0009-9120(02)00320-x. View

Simopoulos A . The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother. 2002; 56(8):365-79. DOI: 10.1016/s0753-3322(02)00253-6. View

Jirillo E, Caccavo D, Magrone T, Piccigallo E, Amati L, Lembo A . The role of the liver in the response to LPS: experimental and clinical findings. J Endotoxin Res. 2003; 8(5):319-27. DOI: 10.1179/096805102125000641. View

Musso G, Gambino R, De Michieli F, Cassader M, Rizzetto M, Durazzo M . Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology. 2003; 37(4):909-16. DOI: 10.1053/jhep.2003.50132. View

Foster G, Wyatt H, Hill J, McGuckin B, Brill C, Mohammed B . A randomized trial of a low-carbohydrate diet for obesity. N Engl J Med. 2003; 348(21):2082-90. DOI: 10.1056/NEJMoa022207. View

Araya J, Rodrigo R, Videla L, Thielemann L, Orellana M, Pettinelli P . Increase in long-chain polyunsaturated fatty acid n - 6/n - 3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond). 2004; 106(6):635-43. DOI: 10.1042/CS20030326. View

Song Y, Manson J, Buring J, Liu S . A prospective study of red meat consumption and type 2 diabetes in middle-aged and elderly women: the women's health study. Diabetes Care. 2004; 27(9):2108-15. DOI: 10.2337/diacare.27.9.2108. View

Esposito K, Marfella R, Ciotola M, Di Palo C, Giugliano F, Giugliano G . Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004; 292(12):1440-6. DOI: 10.1001/jama.292.12.1440. View

Daubioul C, Horsmans Y, Lambert P, Danse E, Delzenne N . Effects of oligofructose on glucose and lipid metabolism in patients with nonalcoholic steatohepatitis: results of a pilot study. Eur J Clin Nutr. 2005; 59(5):723-6. DOI: 10.1038/sj.ejcn.1602127. View

10.

Nordmann A, Nordmann A, Briel M, Keller U, Yancy Jr W, Brehm B . Effects of low-carbohydrate vs low-fat diets on weight loss and cardiovascular risk factors: a meta-analysis of randomized controlled trials. Arch Intern Med. 2006; 166(3):285-93. DOI: 10.1001/archinte.166.3.285. View

11.

Gomez-Ambrosi J, Salvador J, Rotellar F, Silva C, Catalan V, Rodriguez A . Increased serum amyloid A concentrations in morbid obesity decrease after gastric bypass. Obes Surg. 2006; 16(3):262-9. DOI: 10.1381/096089206776116525. View

12.

Capanni M, Calella F, Biagini M, Genise S, Raimondi L, Bedogni G . Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease: a pilot study. Aliment Pharmacol Ther. 2006; 23(8):1143-51. DOI: 10.1111/j.1365-2036.2006.02885.x. View

13.

Cortez-Pinto H, Jesus L, Barros H, Lopes C, Moura M, Camilo M . How different is the dietary pattern in non-alcoholic steatohepatitis patients?. Clin Nutr. 2006; 25(5):816-23. DOI: 10.1016/j.clnu.2006.01.027. View

14.

Toshimitsu K, Matsuura B, Ohkubo I, Niiya T, Furukawa S, Hiasa Y . Dietary habits and nutrient intake in non-alcoholic steatohepatitis. Nutrition. 2006; 23(1):46-52. DOI: 10.1016/j.nut.2006.09.004. View

15.

Ley R, Turnbaugh P, Klein S, Gordon J . Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444(7122):1022-3. DOI: 10.1038/4441022a. View

16.

Tendler D, Lin S, Yancy Jr W, Mavropoulos J, Sylvestre P, Rockey D . The effect of a low-carbohydrate, ketogenic diet on nonalcoholic fatty liver disease: a pilot study. Dig Dis Sci. 2007; 52(2):589-93. DOI: 10.1007/s10620-006-9433-5. View

17.

Catalan V, Gomez-Ambrosi J, Rodriguez A, Silva C, Rotellar F, Gil M . Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. Clin Endocrinol (Oxf). 2007; 68(2):213-9. DOI: 10.1111/j.1365-2265.2007.03021.x. View

18.

Zelber-Sagi S, Nitzan-Kaluski D, Goldsmith R, Webb M, Blendis L, Halpern Z . Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study. J Hepatol. 2007; 47(5):711-7. DOI: 10.1016/j.jhep.2007.06.020. View

19.

Spadaro L, Magliocco O, Spampinato D, Piro S, Oliveri C, Alagona C . Effects of n-3 polyunsaturated fatty acids in subjects with nonalcoholic fatty liver disease. Dig Liver Dis. 2007; 40(3):194-9. DOI: 10.1016/j.dld.2007.10.003. View

20.

Allard J, Aghdassi E, Mohammed S, Raman M, Avand G, Arendt B . Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): a cross-sectional study. J Hepatol. 2007; 48(2):300-7. DOI: 10.1016/j.jhep.2007.09.009. View