Laminar Air Flow Isolation and Decontamination: a Prospective Randomized Study of the Effects of Prophylactic Systemic Antibiotics in Bone Marrow Transplant Patients

Overview

Journal Infection

Date 1986 May 1

PMID 3089939

Citations 12

Authors

F B Petersen

C D Buckner

R A Clift

S Lee

N Nelson

G W COUNTS

J D Meyers

J E Sanders

P S Stewart

W I Bensinger

Affiliations

Soon will be listed here.

Abstract

122 patients with hematologic malignancies underwent allogeneic marrow transplantation from HLA-matched sibling donors and received one of two forms of infection prophylaxis while granulocytopenic: 1) decontamination and laminar air flow isolation (LAF, 68 patients), and 2) LAF plus prophylactic systemic antibiotics (LAF + PSA, 54 patients). Patients were evaluated for infection acquisition while in isolation. Septicemia occurred in 11 (16%) of the patients in the LAF group and in three (6%) patients in the LAF + PSA group. Fourteen (21%) of the patients in the LAF group and four (7%) patients in the LAF + PSA group had a major local infection. There was no difference in the incidence and severity of graft-versus-host disease or incidence and duration of fever. The addition of prophylactic intravenous broad-spectrum antibiotics for patients isolated in LAF rooms significantly decreased infection acquisition.

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