Antimicrobial Susceptibility Patterns of an Emerging Multidrug Resistant Nosocomial Pathogen:

Overview

Journal Malays J Med Sci

Specialty General Medicine

Date 2019 Mar 23

PMID 30899194

Citations 9

Authors

Rachna Tewari

Deepti Chopra

Rushna Wazahat

Shreya Dhingra

Mridu Dudeja

Affiliations

Soon will be listed here.

Abstract

Multidrug-resistant (MDR) () bacterium, a nosocomial pathogen associated with a high mortality rate and limited therapeutic options have emerged as a serious problem throughout the world. The present study aimed to assess the current levels of antibiotic susceptibility among the isolates of species. The sensitivity patterns were analysed from various clinical specimens obtained from both in-patients and outpatients of a teaching hospital. Isolation was performed on 5% sheep blood agar and MacConkey agar. Urine samples were inoculated into CLED agar. Antibiotic susceptibility was performed by the disc diffusion method. A total of 16,452 samples were collected. The total number of samples positive for species was 67 (0.4%). The highest number of isolates 26 (38.8%) were obtained from urine. Majority 80.3% of the isolates exhibited resistance to three or more classes of antibiotics. All isolates were susceptible to colistin (100%). The susceptibility rate of isolates was 80% for tigecycline and 53.3% for carbapenem. Combination therapies including colistin and tigecycline seem to be the rational treatment for MDR until new alternatives come forward.

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