Recent Advances in the Diagnosis and Treatment of Coats' Disease

Overview

Journal Int Ophthalmol

Specialty Ophthalmology

Date 2019 Mar 22

PMID 30895419

Citations 11

Authors

Xinyue Yang

Chenguang Wang

Guanfang Su

Affiliations

Soon will be listed here.

Abstract

Purpose: To review and summarize the recent progress in the diagnosis and treatment of Coats' disease.

Methods: Literature was collected from Web of Science, Medline and Pubmed, through searching of these keywords: "Coats' disease", "diagnosis" and "treatment".

Results: Coats' disease is characterized by idiopathic leaky retinal vascular telangiectasia and microvascular abnormalities often accompanied by intraretinal or subretinal exudation and retinal detachment. Neovascular glaucoma and phthisis bulbi often occur in advanced cases. Coats' disease has significant diversity in terms of its clinical presentation and morphology. Anti-VEGF therapy combined with laser photocoagulation for early Coats' disease and anti-VEGF therapy combined with minimally invasive vitrectomy for advanced Coats' disease can achieve good efficacy.

Conclusion: Early diagnosis and timely treatment based on clinical stage are critical to retaining the patient's visual function. Patients should be aware that close long-term follow-up is necessary.

Citing Articles

Late presentation of Coats disease in a 12-year-old boy: a case report.

Anastasia R, Yustiarini I, Prakosa A, Widjaja S, Firmansjah M, Sasono W Pan Afr Med J. 2025; 49:36.

PMID: 39886112 PMC: 11781208. DOI: 10.11604/pamj.2024.49.36.45134.

Coats disease presenting with vitreous hemorrhage and neovascular glaucoma.

Selvam A, Gabr H, Paul Chan R, Heiferman M Am J Ophthalmol Case Rep. 2025; 37():102232.

PMID: 39803596 PMC: 11718317. DOI: 10.1016/j.ajoc.2024.102232.

Multimodal imaging diagnosis and analysis of prognostic factors in patients with adult-onset Coats disease.

Zhou W, Zhou H, Liu Y, Li M, Wu X, Liang J Int J Ophthalmol. 2024; 17(8):1469-1476.

PMID: 39156792 PMC: 11286439. DOI: 10.18240/ijo.2024.08.12.

Congenital Malformations of the Eye: A Pictorial Review and Clinico-Radiological Correlations.

Guarnera A, Valente P, Pasquini L, Moltoni G, Randisi F, Carducci C J Ophthalmol. 2024; 2024:5993083.

PMID: 38322500 PMC: 10846927. DOI: 10.1155/2024/5993083.

Triple Trouble with Triple Solutions: A Unique Case Report of a Severe Exudative Retinal Detachment Accompanied by Retinal Traction and Two Retinal Holes in Coats Disease.

Berco E, Elsliger S, Weinberg T, Ghannam W, Shoham-Hazon N Case Rep Ophthalmol. 2024; 15(1):84-91.

PMID: 38288027 PMC: 10824515. DOI: 10.1159/000535821.

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