Influence of Dietary Linoleic Acid on Leucocyte Sodium Transport and Blood Pressure

Overview

Journal Br Med J (Clin Res Ed)

Specialty General Medicine

Date 1986 Aug 2

PMID 3089491

Citations 9

Authors

A M Heagerty

J D Ollerenshaw

D I Robertson

R F Bing

J D Swales

Affiliations

Soon will be listed here.

Abstract

In a randomised double blind study to determine whether an increase in the polyunsaturated fat linoleic acid might influence leucocyte membrane sodium transport 22 normotensive volunteers received an oral supplement of linoleic acid or placebo daily for four weeks. Mean total sodium efflux rose significantly during supplementation with linoleic acid compared with placebo. In addition, all components of lying and standing blood pressure fell, though only the fall in supine systolic pressure was significant. Dietary supplementation with linoleic acid may alter ion fluxes across the cell membrane, presumably through changes in its physicochemical structure. In addition, the change in fat intake may lower blood pressure, though to only a very modest extent.

Citing Articles

The cardiac and haemostatic effects of dietary hempseed.

Rodriguez-Leyva D, Pierce G Nutr Metab (Lond). 2010; 7:32.

PMID: 20409317 PMC: 2868018. DOI: 10.1186/1743-7075-7-32.

Relationship of dietary linoleic acid to blood pressure. The International Study of Macro-Micronutrients and Blood Pressure Study [corrected].

Miura K, Stamler J, Nakagawa H, Elliott P, Ueshima H, Chan Q Hypertension. 2008; 52(2):408-14.

PMID: 18606902 PMC: 6668335. DOI: 10.1161/HYPERTENSIONAHA.108.112383.

Hypertension and dietary fat intake.

Banerjee A J R Soc Med. 1987; 80(10):660-1.

PMID: 3694607 PMC: 1291066. DOI: 10.1177/014107688708001028.

Inadequacy of oleic acids in erythrocytes as a marker for malignancies.

Neoptolemos J, Heagerty A, Nicholson M, James R, Clayton H, Bell P Br Med J (Clin Res Ed). 1987; 294(6580):1157-8.

PMID: 3107737 PMC: 1246308. DOI: 10.1136/bmj.294.6580.1157-d.

Blood pressure: from cells to populations. The Bradshaw lecture 1987.

Swales J J R Coll Physicians Lond. 1988; 22(1):11-5.

PMID: 2828607 PMC: 5379300.

References

Jorgensen P . Isolation and characterization of the components of the sodium pump. Q Rev Biophys. 1974; 7(2):239-74. DOI: 10.1017/s0033583500001426. View

ROSE H, OKLANDER M . IMPROVED PROCEDURE FOR THE EXTRACTION OF LIPIDS FROM HUMAN ERYTHROCYTES. J Lipid Res. 1965; 6:428-31. View

Wei J, Janis R, Daniel E . Calcium accumulation and enzymatic activities of subcellular fractions from aortas and ventricles of genetically hypertensive rats. Circ Res. 1976; 39(1):133-40. DOI: 10.1161/01.res.39.1.133. View

Kernoff P, Willis A, Stone K, Davies J, McNicol G . Antithrombotic potential of dihomo-gamma-linolenic acid in man. Br Med J. 1977; 2(6100):1441-4. PMC: 1632618. DOI: 10.1136/bmj.2.6100.1441. View

Sanders T, Ellis F, Dickerson J . Studies of vegans: the fatty acid composition of plasma choline phosphoglycerides, erythrocytes, adipose tissue, and breast milk, and some indicators of susceptibility to ischemic heart disease in vegans and omnivore controls. Am J Clin Nutr. 1978; 31(5):805-13. DOI: 10.1093/ajcn/31.5.805. View

POSTNOV Y, Orlov S, Pokudin N . Decrease of calcium binding by the red blood cell membrane in spontaneously hypertensive rats and in essential hypertension. Pflugers Arch. 1979; 379(2):191-5. DOI: 10.1007/BF00586947. View

Kishimoto A, Takai Y, Mori T, Kikkawa U, NISHIZUKA Y . Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem. 1980; 255(6):2273-6. View

Meyer P, Garay R, Nazaret C, Dagher G, Bellet M, Broyer M . Inheritance of abnormal erythrocyte cation transport in essential hypertension. Br Med J (Clin Res Ed). 1981; 282(6270):1114-7. PMC: 1505030. DOI: 10.1136/bmj.282.6270.1114. View

Aragon I, Devynck M, Meyer P, Helene C . Evidence for structural changes in erythrocyte membranes of spontaneously hypertension rats. A fluorescence polarization study. Biochem Biophys Res Commun. 1981; 100(2):660-5. DOI: 10.1016/s0006-291x(81)80226-4. View

10.

Woods J, Falk R, Pittman A, Klemmer P, Watson B, Namboodiri K . Increased red-cell sodium-lithium countertransport in normotensive sons of hypertensive parents. N Engl J Med. 1982; 306(10):593-5. DOI: 10.1056/NEJM198203113061007. View

11.

Heagerty A, Milner M, Bing R, Thurston H, Swales J . Leucocyte membrane sodium transport in normotensive populations: dissociation of abnormalities of sodium efflux from raised blood-pressure. Lancet. 1982; 2(8304):894-6. DOI: 10.1016/s0140-6736(82)90865-0. View

12.

Puska P, Iacono J, Nissinen A, Korhonen H, Vartianinen E, Pietinen P . Controlled, randomised trial of the effect of dietary fat on blood pressure. Lancet. 1983; 1(8314-5):1-5. DOI: 10.1016/s0140-6736(83)91556-8. View

13.

Rouse I, Beilin L, Armstrong B, VANDONGEN R . Blood-pressure-lowering effect of a vegetarian diet: controlled trial in normotensive subjects. Lancet. 1983; 1(8314-5):5-10. DOI: 10.1016/s0140-6736(83)91557-x. View

14.

Lorenz R, Spengler U, Fischer S, DUHM J, Weber P . Platelet function, thromboxane formation and blood pressure control during supplementation of the Western diet with cod liver oil. Circulation. 1983; 67(3):504-11. DOI: 10.1161/01.cir.67.3.504. View

15.

Swales J . Ion transport in hypertension. Biosci Rep. 1982; 2(12):967-90. DOI: 10.1007/BF01122165. View

16.

Heagerty A, Bing R, Thurston H, Swales J . Calcium antagonists in hypertension: relation to abnormal sodium transport. Br Med J (Clin Res Ed). 1983; 287(6403):1405-7. PMC: 1549661. DOI: 10.1136/bmj.287.6403.1405. View

17.

Milner M, Heagerty A, Bing R, Thurston H, Swales J . Changes in leucocyte sodium transport in normotensive relatives of hypertensive subjects. Dissociation from blood pressure. Hypertension. 1984; 6(3):369-73. DOI: 10.1161/01.hyp.6.3.369. View

18.

Wood D, Butler S, Riemersma R, Thomson M, Oliver M, Fulton M . Adipose tissue and platelet fatty acids and coronary heart disease in Scottish men. Lancet. 1984; 2(8395):117-21. DOI: 10.1016/s0140-6736(84)91044-4. View

19.

Tokumura A, Mostafa M, Nelson D, HANAHAN D . Stimulation of (Ca2+ + Mg2+)-ATPase activity in human erythrocyte membranes by synthetic lysophosphatidic acids and lysophosphatidylcholines. Effects of chain length and degree of unsaturation of the fatty acid groups. Biochim Biophys Acta. 1985; 812(2):568-74. DOI: 10.1016/0005-2736(85)90332-3. View

20.

POSTNOV Y, Orlov S . Cell membrane alteration as a source of primary hypertension. J Hypertens. 1984; 2(1):1-6. DOI: 10.1097/00004872-198402000-00001. View