The Effects of 7-week Cognitive Training in Patients with Vascular Cognitive Impairment, No Dementia (the Cog-VACCINE Study): A Randomized Controlled Trial

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2019 Mar 22

PMID 30894299

Citations 28

Authors

Yi Tang

Yi Xing

Zude Zhu

Yong He

Fang Li

Jianwei Yang

Qing Liu

Fangyu Li

Stefan J Teipel

Guoguang Zhao

Jianping Jia

Affiliations

Soon will be listed here.

Abstract

Introduction: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking.

Methods: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes) and brain functional connectivity and structural changes (secondary outcomes).

Results: Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P = .013) and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P = .017).

Discussion: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials.

Citing Articles

The efficacy of computerized cognitive training in patients with coronary heart disease and cognitive impairment, no dementia: study protocol for a randomized controlled trial.

Ye Y, Chen Q, Li R, Wang X, Sun Y, Li F Trials. 2025; 26(1):64.

PMID: 39985041 PMC: 11844177. DOI: 10.1186/s13063-025-08745-6.

Canadian Stroke Best Practice Recommendations: Vascular cognitive impairment, 7th edition practice guidelines update, 2024.

Swartz R, Longman R, Lindsay M, Lund R, Ganesh A, Eskes G Alzheimers Dement. 2025; 21(1):e14324.

PMID: 39822128 PMC: 11772713. DOI: 10.1002/alz.14324.

Efficacy of home based computerized adaptive cognitive training in patients with post stroke cognitive impairment: a randomized controlled trial.

Soni A, Kumar M, Kothari S Sci Rep. 2025; 15(1):1072.

PMID: 39774282 PMC: 11707344. DOI: 10.1038/s41598-025-85511-3.

Vascular cognitive impairment and dementia: a narrative review.

Jimenez-Ruiz A, Aguilar-Fuentes V, Becerra-Aguiar N, Roque-Sanchez I, Ruiz-Sandoval J Dement Neuropsychol. 2024; 18:e20230116.

PMID: 39318380 PMC: 11421556. DOI: 10.1590/1980-5764-DN-2023-0116.

Dose-response relationship between computerized cognitive training and cognitive improvement.

Liu L, Wang H, Xing Y, Zhang Z, Zhang Q, Dong M NPJ Digit Med. 2024; 7(1):214.

PMID: 39147783 PMC: 11327304. DOI: 10.1038/s41746-024-01210-9.