Antibiotic Resistance in Pacific Island Countries and Territories: A Systematic Scoping Review

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2019 Mar 22

PMID 30893880

Citations 13

Authors

Nicola D Foxlee

Nicola Townell

Lachlan McIver

Colleen L Lau

Affiliations

Soon will be listed here.

Abstract

Several studies have investigated antimicrobial resistance in low- and middle-income countries, but to date little attention has been paid to the Pacific Islands Countries and Territories (PICTs). This study aims to review the literature on antibiotic resistance (ABR) in healthcare settings in PICTs to inform further research and future policy development for the region. Following the PRISMA-ScR checklist health databases and grey literature sources were searched. Three reviewers independently screened the literature for inclusion, data was extracted using a charting tool and the results were described and synthesised. Sixty-five studies about ABR in PICTs were identified and these are primarily about New Caledonia, Fiji and Papua New Guinea. Ten PICTs contributed the remaining 21 studies and nine PICTs were not represented. The predominant gram-positive pathogen reported was community-acquired methicillin resistant and the rates of resistance ranged widely (>50% to <20%). Resistance reported in gram-negative pathogens was mainly associated with healthcare-associated infections (HCAIs). Extended spectrum beta-lactamase (ESBL) producing isolates were reported in New Caledonia (3.4%) and Fiji (22%) and carbapenem resistant isolates in the French Territories (24.8%). ABR is a problem in the PICTs, but the epidemiology requires further characterisation. Action on strengthening surveillance in PICTs needs to be prioritised so strategies to contain ABR can be fully realised.

Citing Articles

Waterborne polyurethane nanoparticles incorporating linoleic acid as a potential strategy for controlling antibiotic resistance spread in the mammalian intestine.

Li G, Han L, Xia L, Gao A, Li Z, Zhou S Mater Today Bio. 2024; 28:101181.

PMID: 39221217 PMC: 11364912. DOI: 10.1016/j.mtbio.2024.101181.

The changing epidemiology of antimicrobial resistance in Fiji: a descriptive analysis of antimicrobial susceptibility and trends of endemic and emerging pathogens, 2019-2022.

Getahun Strobel A, Prasad P, Lane C, Naidu R, Autar S, Young-Sharma T Lancet Reg Health West Pac. 2024; 45:101036.

PMID: 38516290 PMC: 10955629. DOI: 10.1016/j.lanwpc.2024.101036.

Antimicrobial Resistance in Papua New Guinea: A Narrative Scoping Review.

Page B, Adiunegiya S Antibiotics (Basel). 2023; 12(12).

PMID: 38136713 PMC: 10741211. DOI: 10.3390/antibiotics12121679.

The Impact of COVID-19 on Knowledge, Beliefs, and Practices of Ni-Vanuatu Health Workers Regarding Antibiotic Prescribing and Antibiotic Resistance, 2018 and 2022: A Mixed Methods Study.

Foxlee N, Taleo S, Mathias A, Townell N, McIver L, Lau C Trop Med Infect Dis. 2023; 8(10).

PMID: 37888605 PMC: 10611053. DOI: 10.3390/tropicalmed8100477.

Ertapenem Supplemented Selective Media as a New Strategy to Distinguish β-Lactam-Resistant Enterobacterales: Application to Clinical and Wastewater Samples.

Bourles A, Kainiu M, Ukeiwe D, Brunet N, Despaux C, Biron A Antibiotics (Basel). 2023; 12(2).

PMID: 36830303 PMC: 9952050. DOI: 10.3390/antibiotics12020392.

References

Duke T, Michael A . Increase in sepsis due to multi-resistant enteric gram-negative bacilli in Papua New Guinea. Lancet. 1999; 353(9171):2210-1. DOI: 10.1016/S0140-6736(99)02389-2. View

Duke T . Antibiotic-resistant bacterial sepsis in Papua New Guinea. P N G Med J. 2001; 43(1-2):82-90. View

Gosbell I, Mercer J, Neville S, Crone S, Chant K, Jalaludin B . Non-multiresistant and multiresistant methicillin-resistant Staphylococcus aureus in community-acquired infections. Med J Aust. 2001; 174(12):627-30. DOI: 10.5694/j.1326-5377.2001.tb143470.x. View

Duke T, Michael A, Mokela D, Wal T, Reeder J . Chloramphenicol or ceftriaxone, or both, as treatment for meningitis in developing countries?. Arch Dis Child. 2003; 88(6):536-9. PMC: 1763115. DOI: 10.1136/adc.88.6.536. View

Trevett A, Sengupta S . Gentamicin resistance in fatal Klebsiella septicaemia. P N G Med J. 1992; 35(3):202-4. View

MARKHAM N, Stenhouse A . A bacteriological investigation of wound infections in Rarotonga, Cook Islands. Trans R Soc Trop Med Hyg. 1959; 53:404-9. DOI: 10.1016/0035-9203(59)90042-2. View

Wandi F, Kiagi G, Duke T . Long-term outcome for children with bacterial meningitis in rural Papua New Guinea. J Trop Pediatr. 2004; 51(1):51-3. DOI: 10.1093/tropej/fmh075. View

Weber J . Community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2005; 41 Suppl 4:S269-72. DOI: 10.1086/430788. View

Okeke I, Laxminarayan R, Bhutta Z, Duse A, Jenkins P, OBrien T . Antimicrobial resistance in developing countries. Part I: recent trends and current status. Lancet Infect Dis. 2005; 5(8):481-93. DOI: 10.1016/S1473-3099(05)70189-4. View

10.

Naas T, Levy M, Hirschauer C, Marchandin H, Nordmann P . Outbreak of carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-23 in a tertiary care hospital of Papeete, French Polynesia. J Clin Microbiol. 2005; 43(9):4826-9. PMC: 1234128. DOI: 10.1128/JCM.43.9.4826-4829.2005. View

11.

Charveriat M, Chomarat M, Watson M, Garin B . [Nasopharyngeal carriage of Streptococcus pneumoniae in healthy children, 2 to 24 months of age, in New-Caledonia]. Med Mal Infect. 2005; 35(10):500-6. DOI: 10.1016/j.medmal.2005.08.009. View

12.

Miles F, Voss L, Segedin E, Anderson B . Review of Staphylococcus aureus infections requiring admission to a paediatric intensive care unit. Arch Dis Child. 2005; 90(12):1274-8. PMC: 1720228. DOI: 10.1136/adc.2005.074229. View

13.

Michel N, Watson M, Baumann F, Perolat P, Garin B . Distribution of Streptococcus pneumoniae serotypes responsible for penicillin resistance and the potential role of new conjugate vaccines in New Caledonia. J Clin Microbiol. 2005; 43(12):6060-3. PMC: 1317162. DOI: 10.1128/JCM.43.12.6060-6063.2005. View

14.

Vernel-Pauillac F, Falcot V, Whiley D, Merien F . Rapid detection of a chromosomally mediated penicillin resistance-associated ponA mutation in Neisseria gonorrhoeae using a real-time PCR assay. FEMS Microbiol Lett. 2006; 255(1):66-74. DOI: 10.1111/j.1574-6968.2005.00053.x. View

15.

Garin B, Barny S, Lechevallier S, Agathe-Nerine J . [First case of infection due to vancomycin resistant Enterococcus faecalis in New Caledonia]. Med Mal Infect. 2006; 36(5):297-8. DOI: 10.1016/j.medmal.2005.08.012. View

16.

Russell F, Carapetis J, Ketaiwai S, Kunabuli V, Taoi M, Biribo S . Pneumococcal nasopharyngeal carriage and patterns of penicillin resistance in young children in Fiji. Ann Trop Paediatr. 2006; 26(3):187-97. DOI: 10.1179/146532806X120273. View

17.

Gratten M, Montgomery J . The bacteriology of acute pneumonia and meningitis in children in Papua New Guinea: assumptions, facts and technical strategies. P N G Med J. 1991; 34(3):185-98. View

18.

Grayson M, Eliopoulos G, Wennersten C, Ruoff K, De Girolami P, Ferraro M . Increasing resistance to beta-lactam antibiotics among clinical isolates of Enterococcus faecium: a 22-year review at one institution. Antimicrob Agents Chemother. 1991; 35(11):2180-4. PMC: 245356. DOI: 10.1128/AAC.35.11.2180. View

19.

Watson C . Death from multi-resistant shigelloses: a case study from Fiji. Pac Health Dialog. 2008; 13(2):111-4. View

20.

Vernel-Pauillac F, Nandi S, Nicholas R, Goarant C . Genotyping as a tool for antibiotic resistance surveillance of Neisseria gonorrhoeae in New Caledonia: evidence of a novel genotype associated with reduced penicillin susceptibility. Antimicrob Agents Chemother. 2008; 52(9):3293-300. PMC: 2533457. DOI: 10.1128/AAC.00020-08. View