Health-related Quality of Life in Slovenian Patients with Colorectal Cancer: a Single Tertiary Care Center Study

Overview

Journal Radiol Oncol

Publisher Sciendo

Specialties Oncology
Radiology

Date 2019 Mar 21

PMID 30893057

Citations 5

Authors

Jan Grosek

Jerica Novak

Katja Kitek

Alta Bajric

Ana Majdic

Jurij Ales Kosir

Ales Tomazic

Affiliations

Soon will be listed here.

Abstract

Background The aim of this study was to evaluate the influence of the surgical treatment on Slovenian colorectal cancer patients' health-related quality of life and to compare the results to the health-related quality of life of the general Slovenian population. Patients and methods A total of 413 patients with colorectal cancer operated on at the Abdominal Surgery Department at the Ljubljana University Medical Center between January 1st, 2016 and December 31st, 2017 were sent two standardized and validated questionnaires: the EORTC QLQ-C30 version 3 and EORTC QLQ-CR29. The questionnaires were returned by 197 patients. Results Compared to the general population, poorer physical (p < 0.001), role (p = 0.002), cognitive (p = 0.021), and social functioning (p < 0.001) with higher frequency of constipation (p < 0.001), diarrhea (p < 0.001), and financial difficulties (p < 0.001) were reported by the colorectal patients. Female patients reported lower cognitive (p = 0.034) and emotional (p = 0.008) functioning, as well as higher frequency of bloating (p = 0.049) and hair loss (p = 0.01). Compared to the younger group of patients, lower physical functioning (p < 0.001) and higher urinary frequency (p = 0.007), urinary incontinence (p = 0.007), buttock pain (p = 0.007), and anxiety regarding body weight (p = 0.031) were detected among the older group of colorectal patients. Conclusions The global health status of colorectal patients in Slovenia is comparable to that of the general Slovenian population, but there is a significantly lower level in some of the quality-of-life scales.

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PMID: 31636722 PMC: 6778418. DOI: 10.2478/sjph-2019-0019.

References

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

Averyt J, Nishimoto P . Psychosocial issues in colorectal cancer survivorship: the top ten questions patients may not be asking. J Gastrointest Oncol. 2014; 5(5):395-400. PMC: 4173044. DOI: 10.3978/j.issn.2078-6891.2014.058. View

Derogar M, van der Schaaf M, Lagergren P . Reference values for the EORTC QLQ-C30 quality of life questionnaire in a random sample of the Swedish population. Acta Oncol. 2011; 51(1):10-6. DOI: 10.3109/0284186X.2011.614636. View

Zadnik V, Primic Zakelj M, Lokar K, Jarm K, Ivanus U, Zagar T . Cancer burden in slovenia with the time trends analysis. Radiol Oncol. 2017; 51(1):47-55. PMC: 5330174. DOI: 10.1515/raon-2017-0008. View

Juul T, Petersen M, Holzner B, Laurberg S, Christensen P, Gronvold M . Danish population-based reference data for the EORTC QLQ-C30: associations with gender, age and morbidity. Qual Life Res. 2014; 23(8):2183-93. DOI: 10.1007/s11136-014-0675-y. View

Pucciarelli S, Del Bianco P, Toppan P, Serpentini S, Efficace F, Pasetto L . Health-related quality of life outcomes in disease-free survivors of mid-low rectal cancer after curative surgery. Ann Surg Oncol. 2008; 15(7):1846-54. DOI: 10.1245/s10434-008-9923-0. View

Adams S, Ceballos R, Newcomb P . Quality of Life and Mortality of Long-Term Colorectal Cancer Survivors in the Seattle Colorectal Cancer Family Registry. PLoS One. 2016; 11(6):e0156534. PMC: 4890809. DOI: 10.1371/journal.pone.0156534. View

Hamashima C . Long-term quality of life of postoperative rectal cancer patients. J Gastroenterol Hepatol. 2002; 17(5):571-6. DOI: 10.1046/j.1440-1746.2002.02712.x. View

Ramsey S, Berry K, Moinpour C, Giedzinska A, Andersen M . Quality of life in long term survivors of colorectal cancer. Am J Gastroenterol. 2002; 97(5):1228-34. DOI: 10.1111/j.1572-0241.2002.05694.x. View

10.

Sahay T, Gray R, Fitch M . A qualitative study of patient perspectives on colorectal cancer. Cancer Pract. 2000; 8(1):38-44. DOI: 10.1046/j.1523-5394.2000.81012.x. View

11.

Trentham-Dietz A, Remington P, Moinpour C, Hampton J, Sapp A, Newcomb P . Health-related quality of life in female long-term colorectal cancer survivors. Oncologist. 2003; 8(4):342-9. DOI: 10.1634/theoncologist.8-4-342. View

12.

Marventano S, Forjaz M, Grosso G, Mistretta A, Giorgianni G, Platania A . Health related quality of life in colorectal cancer patients: state of the art. BMC Surg. 2013; 13 Suppl 2:S15. PMC: 3851259. DOI: 10.1186/1471-2482-13-S2-S15. View

13.

Hjermstad M, Fayers P, Bjordal K, Kaasa S . Health-related quality of life in the general Norwegian population assessed by the European Organization for Research and Treatment of Cancer Core Quality-of-Life Questionnaire: the QLQ=C30 (+ 3). J Clin Oncol. 1998; 16(3):1188-96. DOI: 10.1200/JCO.1998.16.3.1188. View

14.

Gujral S, Conroy T, Fleissner C, Sezer O, King P, Avery K . Assessing quality of life in patients with colorectal cancer: an update of the EORTC quality of life questionnaire. Eur J Cancer. 2007; 43(10):1564-73. DOI: 10.1016/j.ejca.2007.04.005. View

15.

Aaronson N, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez N . The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993; 85(5):365-76. DOI: 10.1093/jnci/85.5.365. View

16.

Arnold M, Sierra M, Laversanne M, Soerjomataram I, Jemal A, Bray F . Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2016; 66(4):683-691. DOI: 10.1136/gutjnl-2015-310912. View

17.

Jansen L, Koch L, Brenner H, Arndt V . Quality of life among long-term (≥5 years) colorectal cancer survivors--systematic review. Eur J Cancer. 2010; 46(16):2879-88. DOI: 10.1016/j.ejca.2010.06.010. View

18.

Luckett T, King M, Butow P, Oguchi M, Rankin N, Price M . Choosing between the EORTC QLQ-C30 and FACT-G for measuring health-related quality of life in cancer clinical research: issues, evidence and recommendations. Ann Oncol. 2011; 22(10):2179-90. DOI: 10.1093/annonc/mdq721. View

19.

Schmidt C, Bestmann B, Kuchler T, Longo W, Kremer B . Impact of age on quality of life in patients with rectal cancer. World J Surg. 2005; 29(2):190-7. DOI: 10.1007/s00268-004-7556-4. View

20.

Stiggelbout A, Kunneman M, Baas-Thijssen M, Neijenhuis P, Loor A, Jagers S . The EORTC QLQ-CR29 quality of life questionnaire for colorectal cancer: validation of the Dutch version. Qual Life Res. 2015; 25(7):1853-8. PMC: 4893365. DOI: 10.1007/s11136-015-1210-5. View