Innate Immunity in Allergy

Overview

Journal Allergy

Specialty Allergy & Immunology

Date 2019 Mar 21

PMID 30891811

Citations 28

Authors

Kazuhiko Maeda

Matias J Caldez

Shizuo Akira

Affiliations

Soon will be listed here.

Abstract

Innate immune system quickly responds to invasion of microbes and foreign substances through the extracellular and intracellular sensing receptors, which recognize distinctive molecular and structural patterns. The recognition of innate immune receptors leads to the induction of inflammatory and adaptive immune responses by activating downstream signaling pathways. Allergy is an immune-related disease and results from a hypersensitive immune response to harmless substances in the environment. However, less is known about the activation of innate immunity during exposure to allergens. New insights into the innate immune system by sensors and their signaling cascades provide us with more important clues and a framework for understanding allergy disorders. In this review, we will focus on recent advances in the innate immune sensing system.

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