Peripheral and Systemic Antigens Elicit an Expandable Pool of Resident Memory CD8 T Cells in the Bone Marrow

Overview

Journal Eur J Immunol

Specialty Allergy & Immunology

Date 2019 Mar 21

PMID 30891737

Citations 15

Authors

Maria Fernanda Pascutti

Sulima Geerman

Nicholas Collins

Giso Brasser

Benjamin Nota

Regina Stark

Felix Behr

Anna Oja

Edith Slot

Eleni Panagioti

Julia E Prier

Sarah Hickson

Monika C Wolkers

Mirjam H M Heemskerk

Pleun Hombrink

Ramon Arens

Laura K Mackay

Klaas P J M van Gisbergen

Martijn A Nolte

Affiliations

Soon will be listed here.

Abstract

BM has been put forward as a major reservoir for memory CD8 T cells. In order to fulfill that function, BM should "store" memory CD8 T cells, which in biological terms would require these "stored" memory cells to be in disequilibrium with the circulatory pool. This issue is a matter of ongoing debate. Here, we unequivocally demonstrate that murine and human BM harbors a population of tissue-resident memory CD8 T (T ) cells. These cells develop against various pathogens, independently of BM infection or local antigen recognition. BM CD8 T cells share a transcriptional program with resident lymphoid cells in other tissues; they are polyfunctional cytokine producers and dependent on IL-15, Blimp-1, and Hobit. CD8 T cells reside in the BM parenchyma, but are in close contact with the circulation. Moreover, this pool of resident T cells is not size-restricted and expands upon peripheral antigenic re-challenge. This works extends the role of the BM in the maintenance of CD8 T cell memory to include the preservation of an expandable reservoir of functional, non-recirculating memory CD8 T cells, which develop in response to a large variety of peripheral antigens.

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