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HMGB1 As a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma

Overview
Journal Dis Markers
Publisher Wiley
Specialty Biochemistry
Date 2019 Mar 21
PMID 30891101
Citations 19
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Abstract

Malignant mesothelioma (MM) is a rare, aggressive, and highly lethal cancer that is substantially induced by exposure to asbestos fibers. High-mobility group box 1 (HMGB1) is an intriguing proinflammatory molecule involved in MM. In this review, we describe the possible crucial roles of HMGB1 in carcinogenic mechanisms based on and experimental evidence and outline the clinical findings of epidemiological investigations regarding the possible roles of HMGB1 as a biomarker for MM. We conclude that novel strategies targeting HMGB1 may suppress MM cells and interfere with asbestos-induced inflammation.

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