The Impact of Whole Brain Global Functional Connectivity Density Following MECT in Major Depression: A Follow-Up Study

Overview

Journal Front Psychiatry

Specialty Psychiatry

Date 2019 Mar 21

PMID 30890964

Citations 6

Authors

Xiao Li

Huaqing Meng

Yixiao Fu

Lian Du

Haitang Qiu

Tian Qiu

Qibin Chen

Zhiwei Zhang

Qinghua Luo

Affiliations

Soon will be listed here.

Abstract

To explore the alteration of global functional connectivity density (gFCD) in depressive patients after modified electroconvulsive therapy (MECT) and analyze the relationship between gFCD and clinical outcome. Thirty-seven subjects were evaluated based on the diagnostic criteria of the International Classification of Diseases-10 (ICD-10), consisting of a depressive group (24 patients after follow-ups) and a healthy control group with 13 normal individuals. All participants received Hamilton Depression Scale (HAMD) scores and resting-state functional magnetic resonance imaging scans. The gFCD significantly increased in the posterior-middle insula, the supra-marginal gyrus and the dorsal medial prefrontal cortex (dmPFC) before MECT treatment compared to healthy controlled patients. The gFCD statistically expanded in the perigenual anterior cingulate cortex (pgACC), the orbitofrontal cortex bilaterally and the left-supra-marginal gyrus after MECT, and it decreased notably in the posterior insula. The gFCD in the pgACC and the right orbital frontal cortex of depressive group before MECT showed a positive correlation with HAMD scores with treatment. Conforming to the impact of gFCD in depressive patients after MECT, the aforementioned brain region may become an indicator of MECT effect.

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