Cell Adhesion Molecules in Alzheimer's Disease

Overview

Journal Degener Neurol Neuromuscul Dis

Publisher Dove Medical Press

Date 2019 Mar 21

PMID 30890880

Citations 28

Authors

Malin Wennstrom

Henrietta M Nielsen

Affiliations

Soon will be listed here.

Abstract

Cell adhesion molecules (CAMs) mediate interactions between cells and their surroundings that are vital to processes controlling for cell survival, activation, migration, and plasticity. However, increasing evidence suggests that CAMs also mediate mechanisms involved in several neurological diseases. This article reviews the current knowledge on the role of CAMs in amyloid-β (Aβ) metabolism, cell plasticity, neuroinflammation, and vascular changes, all of which are considered central to the pathogenesis and progression of Alzheimer's disease (AD). This paper also outlines the possible roles of CAMs in current and novel AD treatment strategies.

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