Exceptional Longevity and Polygenic Risk for Cardiovascular Health

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2019 Mar 21

PMID 30889929

Citations 6

Authors

Mary Revelas

Anbupalam Thalamuthu

Christopher Oldmeadow

Tiffany-Jane Evans

Nicola J Armstrong

Carlos Riveros

John B Kwok

Peter R Schofield

Henry Brodaty

Rodney J Scott

John R Attia

Perminder S Sachdev

Karen A Mather

Affiliations

Soon will be listed here.

Abstract

Studies investigating exceptionally long-lived (ELL) individuals, including genetic studies, have linked cardiovascular-related pathways, particularly lipid and cholesterol homeostasis, with longevity. This study explored the genetic profiles of ELL individuals (cases: n = 294, 95⁻106 years; controls: n = 1105, 55⁻65 years) by assessing their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of < 5 × 10. PRS were constructed using GWAS summary data from two exceptional longevity (EL) analyses and eight cardiovascular-related risk factors (lipids) and disease (myocardial infarction, coronary artery disease, stroke) analyses. A higher genetic risk for exceptional longevity (EL) was significantly associated with longevity in our sample (odds ratio (OR) = 1.19⁻1.20, = 0.00804 and 0.00758, respectively). Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing. In conclusion, ELL individuals did not have significantly lower polygenic risk for the majority of the investigated cardiovascular health traits. Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL.

Citing Articles

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