Sublingual Immunotherapy with Recombinant Mal D 1 Downregulates the Allergen-specific Th2 Response

Overview

Journal Allergy

Specialty Allergy & Immunology

Date 2019 Mar 20

PMID 30887520

Citations 8

Authors

Claudia Kitzmuller

Beatrice Jahn-Schmid

Tamar Kinaciyan

Barbara Bohle

Affiliations

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Citing Articles

Update of the S2k guideline on the management of IgE-mediated food allergies.

Worm M, Reese I, Ballmer-Weber B, Beyer K, Bischoff S, Bohle B Allergol Select. 2021; 5:195-243.

PMID: 34263109 PMC: 8276640. DOI: 10.5414/ALX02257E.

Treatment Approaches to Food Allergy.

Bohle B, Werfel T Handb Exp Pharmacol. 2021; 268:173-193.

PMID: 34104993 DOI: 10.1007/164_2021_496.

New Insights in Therapy for Food Allergy.

Mayorga C, Palomares F, Canas J, Perez-Sanchez N, Nunez R, Torres M Foods. 2021; 10(5).

PMID: 34068667 PMC: 8151532. DOI: 10.3390/foods10051037.

Oral birch pollen immunotherapy with apples: Results of a phase II clinical pilot study.

Nothegger B, Reider N, Covaciu C, Cova V, Ahammer L, Eidelpes R Immun Inflamm Dis. 2021; 9(2):503-511.

PMID: 33621436 PMC: 8127540. DOI: 10.1002/iid3.410.

Sublingual Immunotherapy: How Sublingual Allergen Administration Heals Allergic Diseases; Current Perspective about the Mode of Action.

Gotoh M, Kaminuma O Pathogens. 2021; 10(2).

PMID: 33540540 PMC: 7912807. DOI: 10.3390/pathogens10020147.

References

Morita R, Schmitt N, Bentebibel S, Ranganathan R, Bourdery L, Zurawski G . Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity. 2011; 34(1):108-21. PMC: 3046815. DOI: 10.1016/j.immuni.2010.12.012. View

Bonvalet M, Moussu H, Wambre E, Ricarte C, Horiot S, Rimaniol A . Allergen-specific CD4+ T cell responses in peripheral blood do not predict the early onset of clinical efficacy during grass pollen sublingual immunotherapy. Clin Exp Allergy. 2012; 42(12):1745-55. DOI: 10.1111/cea.12015. View

Mobs C, Slotosch C, Loffler H, Jakob T, Hertl M, Pfutzner W . Birch pollen immunotherapy leads to differential induction of regulatory T cells and delayed helper T cell immune deviation. J Immunol. 2010; 184(4):2194-203. DOI: 10.4049/jimmunol.0901379. View

Wambre E, DeLong J, James E, LaFond R, Robinson D, Kwok W . Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy. J Allergy Clin Immunol. 2011; 129(2):544-51, 551.e1-7. PMC: 3268867. DOI: 10.1016/j.jaci.2011.08.034. View

Fanta C, Bohle B, Hirt W, Siemann U, Horak F, Kraft D . Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy. Int Arch Allergy Immunol. 1999; 120(3):218-24. DOI: 10.1159/000024270. View

Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C . Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. 2016; 167(4):1067-1078.e16. DOI: 10.1016/j.cell.2016.09.050. View

Bohle B, Kinaciyan T, Gerstmayr M, Radakovics A, Jahn-Schmid B, Ebner C . Sublingual immunotherapy induces IL-10-producing T regulatory cells, allergen-specific T-cell tolerance, and immune deviation. J Allergy Clin Immunol. 2007; 120(3):707-13. DOI: 10.1016/j.jaci.2007.06.013. View

Kinaciyan T, Nagl B, Faustmann S, Frommlet F, Kopp S, Wolkersdorfer M . Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy. J Allergy Clin Immunol. 2017; 141(3):1002-1008. DOI: 10.1016/j.jaci.2017.07.036. View

Jay D, Nadeau K . Immune mechanisms of sublingual immunotherapy. Curr Allergy Asthma Rep. 2014; 14(11):473. DOI: 10.1007/s11882-014-0473-1. View

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Geroldinger-Simic M, Kinaciyan T, Nagl B, Baumgartner-Durchschlag U, Huber H, Ebner C . Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy. J Allergy Clin Immunol. 2012; 131(1):94-102. DOI: 10.1016/j.jaci.2012.06.039. View