Nutritional and Vitamin Status in Patients with Neuroendocrine Neoplasms

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2019 Mar 20

PMID 30886501

Citations 19

Authors

Dominique Svm Clement

Margot Et Tesselaar

Monique E van Leerdam

Rajaventhan Srirajaskanthan

John K Ramage

Affiliations

Soon will be listed here.

Abstract

Symptoms of gastroenteropancreatic located neuroendocrine neoplasms (GEP-NENs) are often related to food intake and manifest as abdominal pain or diarrhoea which can influence patients nutritional status. Malnutrition is common in cancer patients and influences quality of life, treatment options and survival but is also present in up to 40% of patients with GEP-NENs. As part of malnutrition there are often deficiencies in fat-soluble vitamins, mainly vitamin D. Little knowledge exists on trace elements. Several factors influence the development of malnutrition such as size and localisation of the primary tumour as well as metastases, side effects from treatment but also hormone production of the tumour itself. One of the main influencing factors leading to malnutrition is diarrhoea which leads to dehydration and electrolyte disturbances. Treatment of diarrhoea should be guided by its cause. Screening for malnutrition should be part of routine care in every GEP-NEN patient. Multidisciplinary treatment including dietician support is necessary for all malnourished patients with GEP-NENs.

Citing Articles

Nutritional status and gastroenteropancreatic neuroendocrine neoplasms: lights and shadows with a clinical guide from the NIKE Group.

Vitale G, Gaudenzi G, Oldani M, Pandozzi C, Filice A, Jaafar S Rev Endocr Metab Disord. 2024; .

PMID: 39653986 DOI: 10.1007/s11154-024-09937-2.

Identifying the signature of NAD+ metabolism-related genes for immunotherapy of gastric cancer.

Wen H, Mi Y, Li F, Xue X, Sun X, Zheng P Heliyon. 2024; 10(20):e38823.

PMID: 39640811 PMC: 11620085. DOI: 10.1016/j.heliyon.2024.e38823.

Nutritional aspects in neuroendocrine neoplasms. bridging the gap between dietary interventions and cancer care strategies: a scoping review.

Massironi S, Panzuto F, Zilli A, Rinzivillo M, Ciliberto A, Romano E J Endocrinol Invest. 2024; 48(2):269-281.

PMID: 39395115 PMC: 11785655. DOI: 10.1007/s40618-024-02462-8.

Vitamin Nutritional Status in Patients with Pancreatic Cancer: A Narrative Review.

Azzini E, Furini T, Polito A, Scalfi L, Pinto A, Gasperi V Int J Mol Sci. 2024; 25(9).

PMID: 38732007 PMC: 11084158. DOI: 10.3390/ijms25094773.

Epidemiological profile of neuroendocrine tumors in adults in Brazil.

Pujatti P, Paim V, Goncalves R, Vilhena B, Bergmann A, Thuler L Arch Endocrinol Metab. 2024; 68:e230013.

PMID: 38709149 PMC: 11081052. DOI: 10.20945/2359-4292-2023-0013.

References

Teigen L, Kuchnia A, Nagel E, Price K, Hurt R, Earthman C . Diagnosing clinical malnutrition: Perspectives from the past and implications for the future. Clin Nutr ESPEN. 2018; 26:13-20. DOI: 10.1016/j.clnesp.2018.05.006. View

Cetinkaya R, Aagnes B, Thiis-Evensen E, Tretli S, Bergestuen D, Hansen S . Trends in Incidence of Neuroendocrine Neoplasms in Norway: A Report of 16,075 Cases from 1993 through 2010. Neuroendocrinology. 2015; 104(1):1-10. DOI: 10.1159/000442207. View

van der Lely A, de Herder W . Carcinoid syndrome: diagnosis and medical management. Arq Bras Endocrinol Metabol. 2006; 49(5):850-60. DOI: 10.1590/s0004-27302005000500028. View

Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y . Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States. JAMA Oncol. 2017; 3(10):1335-1342. PMC: 5824320. DOI: 10.1001/jamaoncol.2017.0589. View

Qureshi S, Burch N, Druce M, Hattersley J, Khan S, Gopalakrishnan K . Screening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours: a cross-sectional study. BMJ Open. 2016; 6(5):e010765. PMC: 4861125. DOI: 10.1136/bmjopen-2015-010765. View

Massironi S, Zilli A, Bernasconi S, Fanetti I, Cavalcoli F, Ciafardini C . Impact of Vitamin D on the Clinical Outcome of Gastro-Entero-Pancreatic Neuroendocrine Neoplasms: Report on a Series from a Single Institute. Neuroendocrinology. 2017; 105(4):403-411. DOI: 10.1159/000456619. View

Dominguez-Munoz J, Hieronymus C, Sauerbruch T, Malfertheiner P . Fecal elastase test: evaluation of a new noninvasive pancreatic function test. Am J Gastroenterol. 1995; 90(10):1834-7. View

Eriksson B, Oberg K . Summing up 15 years of somatostatin analog therapy in neuroendocrine tumors: future outlook. Ann Oncol. 1999; 10 Suppl 2:S31-8. DOI: 10.1093/annonc/10.suppl_2.s31. View

Cederholm T, Bosaeus I, Barazzoni R, Bauer J, Van Gossum A, Klek S . Diagnostic criteria for malnutrition - An ESPEN Consensus Statement. Clin Nutr. 2015; 34(3):335-40. DOI: 10.1016/j.clnu.2015.03.001. View

10.

Ho P, BOYAJY L, Greenstein E, Barkan A . Effect of chronic octreotide treatment on intestinal absorption in patients with acromegaly. Dig Dis Sci. 1993; 38(2):309-15. DOI: 10.1007/BF01307549. View

11.

Giovanis P, Garna A, Marcante M, Mascanzoni A, Giusto M . Exacerbation of paraneoplastic syndrome of inappropriate antidiuretic hormone by parenteral nutrition in a patient affected by a large-cell neuroendocrine pancreatic cancer. J Pain Symptom Manage. 2006; 32(5):395-6. DOI: 10.1016/j.jpainsymman.2006.07.008. View

12.

Hoda D, Jatoi A, Burnes J, Loprinzi C, Kelly D . Should patients with advanced, incurable cancers ever be sent home with total parenteral nutrition? A single institution's 20-year experience. Cancer. 2005; 103(4):863-8. DOI: 10.1002/cncr.20824. View

13.

Fearon K, Strasser F, Anker S, Bosaeus I, Bruera E, Fainsinger R . Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011; 12(5):489-95. DOI: 10.1016/S1470-2045(10)70218-7. View

14.

Senesse P, Tadmouri A, Culine S, Dufour P, Seys P, Radji A . A prospective observational study assessing home parenteral nutrition in patients with gastrointestinal cancer: benefits for quality of life. J Pain Symptom Manage. 2014; 49(2):183-191.e2. DOI: 10.1016/j.jpainsymman.2014.05.016. View

15.

Siddiqui I, Ahmed S, Abid S . Update on diagnostic value of breath test in gastrointestinal and liver diseases. World J Gastrointest Pathophysiol. 2016; 7(3):256-65. PMC: 4981765. DOI: 10.4291/wjgp.v7.i3.256. View

16.

Modlin I, Sandor A . An analysis of 8305 cases of carcinoid tumors. Cancer. 1997; 79(4):813-29. DOI: 10.1002/(sici)1097-0142(19970215)79:4<813::aid-cncr19>3.0.co;2-2. View

17.

Sachdev A, Pimentel M . Gastrointestinal bacterial overgrowth: pathogenesis and clinical significance. Ther Adv Chronic Dis. 2013; 4(5):223-31. PMC: 3752184. DOI: 10.1177/2040622313496126. View

18.

Bozzetti F, Cozzaglio L, Biganzoli E, Chiavenna G, De Cicco M, Donati D . Quality of life and length of survival in advanced cancer patients on home parenteral nutrition. Clin Nutr. 2002; 21(4):281-8. DOI: 10.1054/clnu.2002.0560. View

19.

Wedlake L, AHern R, Russell D, Thomas K, Walters J, Andreyev H . Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2009; 30(7):707-17. DOI: 10.1111/j.1365-2036.2009.04081.x. View

20.

Berghofer P, Fragkos K, Baxter J, Forbes A, Joly F, Heinze H . Development and validation of the disease-specific Short Bowel Syndrome-Quality of Life (SBS-QoL™) scale. Clin Nutr. 2013; 32(5):789-96. DOI: 10.1016/j.clnu.2012.12.001. View