Antithrombotics from the Sea: Polysaccharides and Beyond

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2019 Mar 20

PMID 30884850

Citations 21

Authors

Francisca Carvalhal

Ricardo R Cristelo

Diana I S P Resende

Madalena M M Pinto

Emilia Sousa

Marta Correia-da-Silva

Affiliations

Soon will be listed here.

Abstract

Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While there are several reviews highlighting the anticoagulant and antithrombotic activities of marine-derived sulfated polysaccharides, reports including other molecules are sparse. Therefore, the present paper provides an update of the recent progress in marine-derived sulfated polysaccharides and quotes other scaffolds that are being considered for investigation due to their antithrombotic effect.

Citing Articles

Marine Pharmacology in 2019-2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous....

Mayer A, Mayer V, Swanson-Mungerson M, Pierce M, Rodriguez A, Nakamura F Mar Drugs. 2024; 22(7).

PMID: 39057418 PMC: 11278370. DOI: 10.3390/md22070309.

Antiviral Activity of Seaweed against ZIKV.

de S Barros C, Cirne-Santos C, Esteves P, Gomes M, Rabelo V, Santos T Curr Top Med Chem. 2024; 24(18):1589-1598.

PMID: 38797894 DOI: 10.2174/0115680266294503240513044930.

A 70% Ethanol Extract Attenuates RANKL-Induced Osteoclast Activation and HO-Induced Osteoblast Apoptosis In Vitro.

Jeong S, Kim I, Moon H, Kim H, Song B, Choi J Molecules. 2024; 29(8).

PMID: 38675559 PMC: 11052068. DOI: 10.3390/molecules29081741.

Purification of an Acidic Polysaccharide with Anticoagulant Activity from the Marine Sponge .

Nieddu G, Obino G, Ciampelli C, Brunetti A, Cubeddu T, Manconi R Mar Drugs. 2024; 22(3).

PMID: 38535480 PMC: 10971851. DOI: 10.3390/md22030139.

Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains from Swim Bladder: Isolation, Structural Analysis, and Anticoagulant Activity.

Yao Y, Tang H, Ma H, Liu Z, Huang J, Yang X Mar Drugs. 2024; 22(1).

PMID: 38276647 PMC: 10817686. DOI: 10.3390/md22010009.

References

Pereira M, Mulloy B, Mourao P . Structure and anticoagulant activity of sulfated fucans. Comparison between the regular, repetitive, and linear fucans from echinoderms with the more heterogeneous and branched polymers from brown algae. J Biol Chem. 1999; 274(12):7656-67. DOI: 10.1074/jbc.274.12.7656. View

Millet J, Jouault S, Mauray S, Theveniaux J, Sternberg C, Boisson Vidal C . Antithrombotic and anticoagulant activities of a low molecular weight fucoidan by the subcutaneous route. Thromb Haemost. 1999; 81(3):391-5. View

Alves A, Valente A, Vacquier V, Mourao P . Structure of the sulfated alpha-L-fucan from the egg jelly coat of the sea urchin Strongylocentrotus franciscanus: patterns of preferential 2-O- and 4-O-sulfation determine sperm cell recognition. Glycobiology. 1999; 9(9):927-33. DOI: 10.1093/glycob/9.9.927. View

Siddhanta A, Shanmugam M, Mody K, Goswami A, Ramavat B . Sulphated polysaccharides of Codium dwarkense Boergs. from the west coast of India: chemical composition and blood anticoagulant activity. Int J Biol Macromol. 1999; 26(2-3):151-4. DOI: 10.1016/s0141-8130(99)00079-3. View

Chevolot L, Foucault A, Chaubet F, Kervarec N, Sinquin C, Fisher A . Further data on the structure of brown seaweed fucans: relationships with anticoagulant activity. Carbohydr Res. 1999; 319(1-4):154-65. DOI: 10.1016/s0008-6215(99)00127-5. View

Chavante S, Santos E, Oliveira F, Guerrini M, Torri G, Casu B . A novel heparan sulphate with high degree of N-sulphation and high heparin cofactor-II activity from the brine shrimp Artemia franciscana. Int J Biol Macromol. 2000; 27(1):49-57. DOI: 10.1016/s0141-8130(99)00114-2. View

Stead P, Hiscox S, Robinson P, Pike N, Sidebottom P, Roberts A . Eryloside F, a novel penasterol disaccharide possessing potent thrombin receptor antagonist activity. Bioorg Med Chem Lett. 2000; 10(7):661-4. DOI: 10.1016/s0960-894x(00)00063-9. View

Matsubara K, Hori K, Matsuura Y, Miyazawa K . Purification and characterization of a fibrinolytic enzyme and identification of fibrinogen clotting enzyme in a marine green alga, Codium divaricatum. Comp Biochem Physiol B Biochem Mol Biol. 2000; 125(1):137-43. DOI: 10.1016/s0305-0491(99)00161-3. View

Farias W, Valente A, Pereira M, Mourao P . Structure and anticoagulant activity of sulfated galactans. Isolation of a unique sulfated galactan from the red algae Botryocladia occidentalis and comparison of its anticoagulant action with that of sulfated galactans from invertebrates. J Biol Chem. 2000; 275(38):29299-307. DOI: 10.1074/jbc.M002422200. View

10.

Hayakawa Y, Hayashi T, Lee J, Srisomporn P, Maeda M, Ozawa T . Inhibition of thrombin by sulfated polysaccharides isolated from green algae. Biochim Biophys Acta. 2000; 1543(1):86-94. DOI: 10.1016/s0167-4838(00)00193-x. View

11.

Nar H, Bauer M, Schmid A, Stassen J, Wienen W, Priepke H . Structural basis for inhibition promiscuity of dual specific thrombin and factor Xa blood coagulation inhibitors. Structure. 2001; 9(1):29-37. DOI: 10.1016/s0969-2126(00)00551-7. View

12.

Trento F, Cattaneo F, Pescador R, Porta R, Ferro L . Antithrombin activity of an algal polysaccharide. Thromb Res. 2001; 102(5):457-65. DOI: 10.1016/s0049-3848(01)00264-x. View

13.

Vilela-Silva A, Castro M, Valente A, Biermann C, Mourao P . Sulfated fucans from the egg jellies of the closely related sea urchins Strongylocentrotus droebachiensis and Strongylocentrotus pallidus ensure species-specific fertilization. J Biol Chem. 2001; 277(1):379-87. DOI: 10.1074/jbc.M108496200. View

14.

Ruperez P, Ahrazem O, Leal J . Potential antioxidant capacity of sulfated polysaccharides from the edible marine brown seaweed Fucus vesiculosus. J Agric Food Chem. 2002; 50(4):840-5. DOI: 10.1021/jf010908o. View

15.

Varki N, Varki A . Heparin inhibition of selectin-mediated interactions during the hematogenous phase of carcinoma metastasis: rationale for clinical studies in humans. Semin Thromb Hemost. 2002; 28(1):53-66. DOI: 10.1055/s-2002-20564. View

16.

Pavao M . Structure and anticoagulant properties of sulfated glycosaminoglycans from primitive Chordates. An Acad Bras Cienc. 2002; 74(1):105-12. DOI: 10.1590/s0001-37652002000100007. View

17.

Wang L, Brown J, Varki A, Esko J . Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest. 2002; 110(1):127-36. PMC: 151027. DOI: 10.1172/JCI14996. View

18.

Pereira M, Melo F, Mourao P . Is there a correlation between structure and anticoagulant action of sulfated galactans and sulfated fucans?. Glycobiology. 2002; 12(10):573-80. DOI: 10.1093/glycob/cwf077. View

19.

Jung W, Je J, Kim H, Kim S . A novel anticoagulant protein from Scapharca broughtonii. J Biochem Mol Biol. 2002; 35(2):199-205. DOI: 10.5483/bmbrep.2002.35.2.199. View

20.

Carroll A, Pierens G, Fechner G, de Almeida Leone P, Ngo A, Simpson M . Dysinosin A: a novel inhibitor of Factor VIIa and thrombin from a new genus and species of Australian sponge of the family Dysideidae. J Am Chem Soc. 2002; 124(45):13340-1. DOI: 10.1021/ja020814a. View