Spatially Specific Liposomal Cancer Therapy Triggered by Clinical External Sources of Energy

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2019 Mar 20

PMID 30884786

Citations 9

Authors

Courtney van Ballegooie

Alice Man

Mi Win

Donald T Yapp

Affiliations

Soon will be listed here.

Abstract

This review explores the use of energy sources, including ultrasound, magnetic fields, and external beam radiation, to trigger the delivery of drugs from liposomes in a tumor in a spatially-specific manner. Each section explores the mechanism(s) of drug release that can be achieved using liposomes in conjunction with the external trigger. Subsequently, the treatment's formulation factors are discussed, highlighting the parameters of both the therapy and the medical device. Additionally, the pre-clinical and clinical trials of each triggered release method are explored. Lastly, the advantages and disadvantages, as well as the feasibility and future outlook of each triggered release method, are discussed.

Citing Articles

Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review.

Bahutair W, Abuwatfa W, Husseini G Nanomaterials (Basel). 2022; 12(17).

PMID: 36080088 PMC: 9458162. DOI: 10.3390/nano12173051.

Effects of Lipid Shape and Interactions on the Conformation, Dynamics, and Curvature of Ultrasound-Responsive Liposomes.

Lee H, Moon H, Kim H Pharmaceutics. 2022; 14(7).

PMID: 35890407 PMC: 9320727. DOI: 10.3390/pharmaceutics14071512.

In vivo acoustic manipulation of microparticles in zebrafish embryos.

Jooss V, Bolten J, Huwyler J, Ahmed D Sci Adv. 2022; 8(12):eabm2785.

PMID: 35333569 PMC: 8956268. DOI: 10.1126/sciadv.abm2785.

Gold-Protein Composite Nanoparticles for Enhanced X-ray Interactions: A Potential Formulation for Triggered Release.

van Ballegooie C, Man A, Pallaoro A, Bally M, Gates B, Yapp D Pharmaceutics. 2021; 13(9).

PMID: 34575482 PMC: 8471296. DOI: 10.3390/pharmaceutics13091407.

Recent advances in liposome formulations for breast cancer therapeutics.

Yang B, Song B, Shankar S, Guller A, Deng W Cell Mol Life Sci. 2021; 78(13):5225-5243.

PMID: 33974093 PMC: 11071878. DOI: 10.1007/s00018-021-03850-6.

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