Human Chorionic Gonadotrophin Pharmaceutical Formulations of Urinary Origin Display High Levels of Contaminant Proteins-A Label-free Quantitation Proteomics Study

Overview

Journal Electrophoresis

Specialty Chemistry

Date 2019 Mar 19

PMID 30883802

Citations 1

Authors

Tanja Panic-Jankovic

Goran Mitulovic

Affiliations

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Abstract

To determine whether there is a measurable protein background in different formulations of urinary and recombinant human chorionic gonadotropin (hCG). Primary outcome measures: identification of contaminant proteins in urinary-derived formulations of hCG; secondary outcome measures: quantitative values of contaminant proteins in different batches of urinary -derived hCG formulations. It was found that urinary-derived batches have high presence of contaminant proteins beside the active substance. The relative amount of contaminant proteins and hCG differs strongly between different batches.

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