Exercise and Vascular Insulin Sensitivity in the Skeletal Muscle and Brain

Overview

Journal Exerc Sport Sci Rev

Specialty Orthopedics

Date 2019 Mar 19

PMID 30883470

Citations 9

Authors

T Dylan Olver

M Harold Laughlin

Jaume Padilla

Affiliations

Soon will be listed here.

Abstract

We present the hypothesis that exercise-induced hyperemia, perhaps through vascular shear stress, represents an important factor responsible for the effects of physical activity (PA) on vascular insulin sensitivity. Specifically, we postulate PA involving the greatest amount of skeletal muscle mass and the greatest central neural recruitment maximizes perfusion and consequently enhances vascular insulin sensitivity in the skeletal muscle and brain.

Citing Articles

Dose-Response Relationship Between Physical Activity and the Morbidity and Mortality of Cardiovascular Disease Among Individuals With Diabetes: Meta-Analysis of Prospective Cohort Studies.

Chen Y, Jin X, Chen G, Wang R, Tian H JMIR Public Health Surveill. 2024; 10:e54318.

PMID: 38780218 PMC: 11369533. DOI: 10.2196/54318.

Comparing prophylactic effect of exercise and metformin on cognitive brain functions in rats with type 3 diabetes mellitus.

Sakr H, Amen M, Rashed L, Khowailed A, Sayed H, Motawee M Arch Med Sci. 2024; 20(2):618-631.

PMID: 38757028 PMC: 11094824. DOI: 10.5114/aoms.2020.99023.

Intermediate versus morning chronotype has lower vascular insulin sensitivity in adults with obesity.

Malin S, Remchak M, Heiston E, Battillo D, Gow A, Shah A Diabetes Obes Metab. 2024; 26(5):1582-1592.

PMID: 38246697 PMC: 11001524. DOI: 10.1111/dom.15456.

New insights into mechanisms of endothelial insulin resistance in type 2 diabetes.

Padilla J, Manrique-Acevedo C, Martinez-Lemus L Am J Physiol Heart Circ Physiol. 2022; 323(6):H1231-H1238.

PMID: 36331555 PMC: 9705017. DOI: 10.1152/ajpheart.00537.2022.

Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking.

Park L, Parks E, Pettit-Mee R, Woodford M, Ghiarone T, Smith J J Appl Physiol (1985). 2020; 129(2):283-296.

PMID: 32614687 PMC: 7473951. DOI: 10.1152/japplphysiol.00174.2020.

References

Sexton W, Korthuis R, Laughlin M . High-intensity exercise training increases vascular transport capacity of rat hindquarters. Am J Physiol. 1988; 254(2 Pt 2):H274-8. DOI: 10.1152/ajpheart.1988.254.2.H274. View

Creager M, Liang C, COFFMAN J . Beta adrenergic-mediated vasodilator response to insulin in the human forearm. J Pharmacol Exp Ther. 1985; 235(3):709-14. View

Sexton W, Laughlin M . Influence of endurance exercise training on distribution of vascular adaptations in rat skeletal muscle. Am J Physiol. 1994; 266(2 Pt 2):H483-90. DOI: 10.1152/ajpheart.1994.266.2.H483. View

McAllister R, Kimani J, Webster J, Parker J, Laughlin M . Effects of exercise training on responses of peripheral and visceral arteries in swine. J Appl Physiol (1985). 1996; 80(1):216-25. DOI: 10.1152/jappl.1996.80.1.216. View

Olver T, Reid S, Smith A, Zamir M, Lemon P, Laughlin M . Effects of acute and chronic interval sprint exercise performed on a manually propelled treadmill on upper limb vascular mechanics in healthy young men. Physiol Rep. 2016; 4(13). PMC: 4945842. DOI: 10.14814/phy2.12861. View

Eringa E, Stehouwer C, Roos M, Westerhof N, Sipkema P . Selective resistance to vasoactive effects of insulin in muscle resistance arteries of obese Zucker (fa/fa) rats. Am J Physiol Endocrinol Metab. 2007; 293(5):E1134-9. DOI: 10.1152/ajpendo.00516.2006. View

Eskelinen J, Heinonen I, Loyttyniemi E, Saunavaara V, Kirjavainen A, Virtanen K . Muscle-specific glucose and free fatty acid uptake after sprint interval and moderate-intensity training in healthy middle-aged men. J Appl Physiol (1985). 2015; 118(9):1172-80. DOI: 10.1152/japplphysiol.01122.2014. View

Kim H, Sam Lee J, Kim C . Effect of exercise training on muscle glucose transporter 4 protein and intramuscular lipid content in elderly men with impaired glucose tolerance. Eur J Appl Physiol. 2004; 93(3):353-8. DOI: 10.1007/s00421-004-1214-2. View

Dela F, Mikines K, Larsen J, Galbo H . Training-induced enhancement of insulin action in human skeletal muscle: the influence of aging. J Gerontol A Biol Sci Med Sci. 1996; 51(4):B247-52. DOI: 10.1093/gerona/51a.4.b247. View

10.

Mackie B, Terjung R . Blood flow to different skeletal muscle fiber types during contraction. Am J Physiol. 1983; 245(2):H265-75. DOI: 10.1152/ajpheart.1983.245.2.H265. View

11.

CLAUSEN J, TRAP-JENSEN J . Effects of training on the distribution of cardiac output in patients with coronary artery disease. Circulation. 1970; 42(4):611-24. DOI: 10.1161/01.cir.42.4.611. View

12.

Musch T, Haidet G, Ordway G, Longhurst J, Mitchell J . Training effects on regional blood flow response to maximal exercise in foxhounds. J Appl Physiol (1985). 1987; 62(4):1724-32. DOI: 10.1152/jappl.1987.62.4.1724. View

13.

Padilla J, Olver T, Thyfault J, Fadel P . Role of habitual physical activity in modulating vascular actions of insulin. Exp Physiol. 2015; 100(7):759-71. PMC: 4704106. DOI: 10.1113/EP085107. View

14.

Katakam P, Snipes J, Steed M, Busija D . Insulin-induced generation of reactive oxygen species and uncoupling of nitric oxide synthase underlie the cerebrovascular insulin resistance in obese rats. J Cereb Blood Flow Metab. 2012; 32(5):792-804. PMC: 3345912. DOI: 10.1038/jcbfm.2011.181. View

15.

Dwyer D, Browning J, Weinstein S . The reliability of muscle biopsies taken from vastus lateralis. J Sci Med Sport. 2000; 2(4):333-40. DOI: 10.1016/s1440-2440(99)80006-1. View

16.

Dela F, Larsen J, Mikines K, Ploug T, Petersen L, Galbo H . Insulin-stimulated muscle glucose clearance in patients with NIDDM. Effects of one-legged physical training. Diabetes. 1995; 44(9):1010-20. DOI: 10.2337/diab.44.9.1010. View

17.

Schmidt W, Endres M, Dimeo F, Jungehulsing G . Train the vessel, gain the brain: physical activity and vessel function and the impact on stroke prevention and outcome in cerebrovascular disease. Cerebrovasc Dis. 2013; 35(4):303-12. DOI: 10.1159/000347061. View

18.

Delp M, McAllister R, Laughlin M . Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. J Appl Physiol (1985). 1993; 75(3):1354-63. DOI: 10.1152/jappl.1993.75.3.1354. View

19.

Bakker W, Sipkema P, Stehouwer C, Serne E, Smulders Y, van Hinsbergh V . Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries. Diabetes. 2007; 57(3):706-13. DOI: 10.2337/db07-0792. View

20.

Delp M, Laughlin M . Time course of enhanced endothelium-mediated dilation in aorta of trained rats. Med Sci Sports Exerc. 1997; 29(11):1454-61. DOI: 10.1097/00005768-199711000-00011. View