Effects of Prenatal Exposure to Temephos on Behavior and Social Interaction

Overview

Journal Neuropsychiatr Dis Treat

Publisher Dove Medical Press

Specialty Psychiatry

Date 2019 Mar 19

PMID 30880993

Citations 4

Authors

Ana Olivia Martins Laurentino

Fabiana Durante de Medeiros

Juliana de Oliveira

Naiana da Rosa

Tamires Mateus Gomes

Eduardo de Medeiros Peretti

Josiane Somariva Prophiro

JucElia J Fortunato

Affiliations

Soon will be listed here.

Abstract

Purpose: To evaluate behavioral effects of prenatal exposition to temephos in rats.

Methods: First, we divided pregnant females into groups: those who received temephos diluted in distilled water by gavage between gestational days 6-13 and those who received only distilled water in the same period and volume. Then, we divided pups according to sex and exposure, and we made the behavioral tests on postnatal day 30.

Results: Prenatal exposure to temephos caused hyperactivity, stereotyped behavior, and social impairment in animals.

Conclusion: These results are similar to the altered behavior presented in some neurobiological diseases models, like Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorders, and this study may bring a red alert to the large use of temephos in Brazil, due to the damage caused by its exposure.

Citing Articles

Analysis of Thiodiphenol in Rat Urine as a Biomarker of Exposure to Temephos.

Shih M, Lopez-Gonzalez M, Uribe-Ramirez M, Rojas-Garcia A, Verdin-Betancourt F, Sierra-Santoyo A J Xenobiot. 2024; 14(4):1889-1900.

PMID: 39728408 PMC: 11677692. DOI: 10.3390/jox14040100.

Synergistic Larvicidal and Pupicidal Toxicity and the Morphological Impact of the Dengue Vector () Induced by Geranial and -Cinnamaldehyde.

Sittichok S, Passara H, Sinthusiri J, Moungthipmalai T, Puwanard C, Murata K Insects. 2024; 15(9).

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Ovicidal toxicity of plant essential oils and their major constituents against two mosquito vectors and their non-target aquatic predators.

Moungthipmalai T, Puwanard C, Aungtikun J, Sittichok S, Soonwera M Sci Rep. 2023; 13(1):2119.

PMID: 36746998 PMC: 9902397. DOI: 10.1038/s41598-023-29421-2.

Combinations of plant essential oils and their major compositions inducing mortality and morphological abnormality of and .

Soonwera M, Moungthipmalai T, Aungtikun J, Sittichok S Heliyon. 2022; 8(5):e09346.

PMID: 35521510 PMC: 9065628. DOI: 10.1016/j.heliyon.2022.e09346.

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